ANKRD15 explained

KN motif and ankyrin repeat domain-containing protein 1 is a protein that in humans is encoded by the KANK1 gene.^{[1] [2] [3]}

This gene encodes a protein containing four ankyrin repeat domains in its C-terminus. The suggested role for this protein is in tumorigenesis of renal cell carcinoma. Two alternatively spliced transcript variants encoding different isoforms have been identified.

Further reading

• Nagase T . Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1 . DNA Res. . 3 . 1 . 17–24 . 1996 . 8724849 . 10.1093/dnares/3.1.17 . Seki N . Ishikawa K . 3 . Tanaka . A . Nomura . N . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Humphray SJ . DNA sequence and analysis of human chromosome 9 . Nature . 429 . 6990 . 369–74 . 2004 . 15164053 . 10.1038/nature02465 . 2734081 . Oliver K . Hunt AR . 3 . Plumb . R. W. . Loveland . J. E. . Howe . K. L. . Andrews . T. D. . Searle . S. . Hunt . S. E. . 2004Natur.429..369H .
• Colland F . Functional Proteomics Mapping of a Human Signaling Pathway . Genome Res. . 14 . 7 . 1324–32 . 2004 . 15231748 . 10.1101/gr.2334104 . 442148 . Jacq X . Trouplin V . 3 . Mougin . C . Groizeleau . C . Hamburger . A . Meil . A . Wojcik . J . Legrain . P .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Roy BC . Pathological characterization of Kank in renal cell carcinoma . Exp. Mol. Pathol. . 78 . 1 . 41–8 . 2005 . 15596059 . 10.1016/j.yexmp.2004.08.012 . Aoyagi T . Sarkar S . 3 . Nomura . K . Kanda . H . Iwaya . K . Tachibana . M . Kiyama . R .
• Wang Y . Alternative splicing of the human Kank gene produces two types of Kank protein . Biochem. Biophys. Res. Commun. . 330 . 4 . 1247–53 . 2005 . 15823577 . 10.1016/j.bbrc.2005.03.106 . Onishi Y . Kakinuma N . 3 . Roy . Badal Chandra . Aoyagi . Teiichiro . Kiyama . Ryoiti .
• Wang Y, Kakinuma N, Zhu Y, Kiyama R . Nucleo-cytoplasmic shuttling of human Kank protein accompanies intracellular translocation of beta-catenin . J. Cell Sci. . 119 . Pt 19 . 4002–10 . 2007 . 16968744 . 10.1242/jcs.03169 . 14196261 .

Notes and References

1. Sarkar S, Roy BC, Hatano N, Aoyagi T, Gohji K, Kiyama R . A novel ankyrin repeat-containing gene (Kank) located at 9p24 is a growth suppressor of renal cell carcinoma . J Biol Chem . 277 . 39 . 36585–91 . Sep 2002 . 12133830 . 10.1074/jbc.M204244200 . free .
2. Zhu Y, Kakinuma N, Wang Y, Kiyama R . Kank proteins: a new family of ankyrin-repeat domain-containing proteins . Biochim Biophys Acta . 1780 . 2 . 128–33 . Jan 2008 . 17996375 . 10.1016/j.bbagen.2007.09.017 .
3. Web site: Entrez Gene: ANKRD15 ankyrin repeat domain 15.