Angiopoietin-related protein 1 explained

Angiopoietin-related protein 1 also known as angiopoietin-3 (ANG-3) is a protein that in humans is encoded by the ANGPTL1 gene.^{[1] [2] [3]}

Function

Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels.

The protein encoded by this gene is another member of the angiopoietin family that is widely expressed in adult tissues with mRNA levels highest in highly vascularized tissues. This protein was found to be a secretory protein that does not act as an endothelial cell mitogen in vitro.^[3]

Further reading

• Dhanabal M, Jeffers M, LaRochelle WJ, Lichenstein HS . Angioarrestin: a unique angiopoietin-related protein with anti-angiogenic properties. . Biochem. Biophys. Res. Commun. . 333 . 2 . 308–15 . 2005 . 15950186 . 10.1016/j.bbrc.2005.05.134 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Valenzuela DM, Griffiths JA, Rojas J . Angiopoietins 3 and 4: diverging gene counterparts in mice and humans. . Proc. Natl. Acad. Sci. U.S.A. . 96 . 5 . 1904–9 . 1999 . 10051567 . 10.1073/pnas.96.5.1904 . 26709 . 1999PNAS...96.1904V . etal. free .
• Avram D, Ishmael JE, Nevrivy DJ . Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2. . J. Biol. Chem. . 274 . 20 . 14331–6 . 1999 . 10318855 . 10.1074/jbc.274.20.14331 . 2823254 . etal. free .
• Kim I, Moon SO, Koh KN . Molecular cloning, expression, and characterization of angiopoietin-related protein. angiopoietin-related protein induces endothelial cell sprouting. . J. Biol. Chem. . 274 . 37 . 26523–8 . 1999 . 10473614 . 10.1074/jbc.274.37.26523 . etal. free .
• Zeng L, Dai J, Ying K . Identification of a novel human angiopoietin-like gene expressed mainly in heart. . J. Hum. Genet. . 48 . 3 . 159–62 . 2003 . 12624729 . 10.1007/s100380300025 . etal. free .
• Lee HJ, Cho CH, Hwang SJ . Biological characterization of angiopoietin-3 and angiopoietin-4. . FASEB J. . 18 . 11 . 1200–8 . 2005 . 15284220 . 10.1096/fj.03-1466com . free . 19001234 . etal.
• Oliner J, Min H, Leal J . Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2. . Cancer Cell . 6 . 5 . 507–16 . 2004 . 15542434 . 10.1016/j.ccr.2004.09.030 . etal. free .
• Smagur A, Szary J, Szala S . Recombinant angioarrestin secreted from mouse melanoma cells inhibits growth of primary tumours. . Acta Biochim. Pol. . 52 . 4 . 875–9 . 2006 . 10.18388/abp.2005_3401 . 15940350 . free .

Notes and References

1. Kim I, Kwak HJ, Ahn JE, So JN, Liu M, Koh KN, Koh GY . Molecular cloning and characterization of a novel angiopoietin family protein, angiopoietin-3 . FEBS Lett . 443 . 3 . 353–6 . Mar 1999 . 10025962 . 10.1016/S0014-5793(99)00008-3 . 27230019 . free .
2. Lemmens I, Merregaert J, Van de Ven WJ, Kas K, Zhang CX, Giraud S, Wautot V, Buisson N, De Witte K, Salandre J, Lenoir G, Calender A, Parente F, Quincey D, Courseaux A, Carle GF, Gaudray P, De Wit MJ, Lips CJ, Hoppener JW, Khodaei S, Grant AL, Weber G, Kytola S, Thakker RV . Construction of a 1.2-Mb sequence-ready contig of chromosome 11q13 encompassing the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1 . Genomics . 44 . 1 . 94–100 . Nov 1997 . 9286704 . 10.1006/geno.1997.4872 . etal.
3. Web site: Entrez Gene: ANGPTL1 angiopoietin-like 1.