ANGPT4 explained

Angiopoietin-4 is a protein that in humans is encoded by the ANGPT4 gene.^{[1] [2] [3]}

Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells.

The protein encoded by this gene functions as an agonist and is an angiopoietin.

Further reading

• Grosios K . Assignment of ANGPT4, ANGPT1, and ANGPT2 encoding angiopoietins 4, 1 and 2 to human chromosome bands 20p13, 8q22.3→q23 and 8p23.1, respectively, by in situ hybridization and radiation hybrid mapping . Cytogenet. Cell Genet. . 84 . 1–2 . 118–20 . 1999 . 10343124 . 10.1159/000015235 . Leek JP . Markham AF . 3 . Yancopoulos . G.D. . Jones . P.F. . 40232421 .
• Hartley JL, Temple GF, Brasch MA . DNA Cloning Using In Vitro Site-Specific Recombination . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
• Deloukas P . The DNA sequence and comparative analysis of human chromosome 20 . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . Matthews LH . Ashurst J . 3 . Burton . J. . Gilbert . J. G. R. . Jones . M. . Stavrides . G. . Almeida . J. P. . Babbage . A. K. . 2001Natur.414..865D . free .
• Ward EG, Grosios K, Markham AF, Jones PF . Genomic structures of the human angiopoietins show polymorphism in angiopoietin-2 . Cytogenet. Cell Genet. . 94 . 3–4 . 147–54 . 2002 . 11856872 . 10.1159/000048807 . 22445942 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Zeng L . Identification of a novel human angiopoietin-like gene expressed mainly in heart . J. Hum. Genet. . 48 . 3 . 159–62 . 2003 . 12624729 . 10.1007/s100380300025 . Dai J . Ying K . 3 . Zhao . E . Jin . W . Ye . Y . Dai . J . Xu . J . Xie . Y . free .
• Yamakawa M . Expression of angiopoietins in renal epithelial and clear cell carcinoma cells: regulation by hypoxia and participation in angiogenesis . Am. J. Physiol. Renal Physiol. . 287 . 4 . F649–57 . 2004 . 15198927 . 10.1152/ajprenal.00028.2004 . Liu LX . Belanger AJ . 3 . Date . T . Kuriyama . T . Goldberg . MA . Cheng . SH . Gregory . RJ . Jiang . C .
• Lee HJ . Biological characterization of angiopoietin-3 and angiopoietin-4 . FASEB J. . 18 . 11 . 1200–8 . 2005 . 15284220 . 10.1096/fj.03-1466com . Cho CH . Hwang SJ . 3 . Choi . HH . Kim . KT . Ahn . SY . Kim . JH . Oh . JL . Lee . GM . free . 19001234 .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Oliner J . Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2 . Cancer Cell . 6 . 5 . 507–16 . 2004 . 15542434 . 10.1016/j.ccr.2004.09.030 . Min H . Leal J . 3 . Yu . Dongyin . Rao . Shashirekha . You . Edward . Tang . Xiu . Kim . Haejin . Meyer . Susanne . free .
• Olsen MW . Angiopoietin-4 Inhibits Angiogenesis and Reduces Interstitial Fluid Pressure . Neoplasia . 8 . 5 . 364–72 . 2006 . 16790085 . 10.1593/neo.06127 . 1592453 . Ley CD . Junker N . 3 . Hansen . Anker J . Lund . Eva L. . Kristjansen . PE .

Notes and References

1. Valenzuela DM, Griffiths JA, Rojas J, Aldrich TH, Jones PF, Zhou H, McClain J, Copeland NG, Gilbert DJ, Jenkins NA, Huang T, Papadopoulos N, Maisonpierre PC, Davis S, Yancopoulos GD . Angiopoietins 3 and 4: Diverging gene counterparts in mice and humans . Proc Natl Acad Sci U S A . 96 . 5 . 1904–9 . Apr 1999 . 10051567 . 26709 . 10.1073/pnas.96.5.1904 . 1999PNAS...96.1904V . free .
2. Nishimura M, Miki T, Yashima R, Yokoi N, Yano H, Sato Y, Seino S . Angiopoietin-3, a novel member of the angiopoietin family . FEBS Lett . 448 . 2–3 . 254–6 . May 1999 . 10218486 . 10.1016/S0014-5793(99)00381-6 . 11265148 .
3. Web site: Entrez Gene: ANGPT4 angiopoietin 4.