ANGPT2 explained

Angiopoietin-2 is a protein that in humans is encoded by the ANGPT2 gene.^[1]

Naturally occurring antagonist for both ANGPT1 and TIE2; expressed only at the sites of vascular remodeling; similar to angiopoietin-1^[2]

Function

• See Angiopoietin#Clinical relevance

Interactions

ANGPT2 has been shown to interact with TEK tyrosine kinase.^{[3] [4] [5]}

See also

• Angiopoietin

Further reading

• Maisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C, Compton D, McClain J, Aldrich TH, Papadopoulos N, Daly TJ, Davis S, Sato TN, Yancopoulos GD . Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis . Science . 277 . 5322 . 55–60 . July 1997 . 9204896 . 10.1126/science.277.5322.55 .
• Sato A, Iwama A, Takakura N, Nishio H, Yancopoulos GD, Suda T . Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells . International Immunology . 10 . 8 . 1217–27 . August 1998 . 9723709 . 10.1093/intimm/10.8.1217 . free .
• Tanaka S, Mori M, Sakamoto Y, Makuuchi M, Sugimachi K, Wands JR . Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma . The Journal of Clinical Investigation . 103 . 3 . 341–5 . February 1999 . 9927494 . 407900 . 10.1172/JCI4891 .
• Valenzuela DM, Griffiths JA, Rojas J, Aldrich TH, Jones PF, Zhou H, McClain J, Copeland NG, Gilbert DJ, Jenkins NA, Huang T, Papadopoulos N, Maisonpierre PC, Davis S, Yancopoulos GD . Angiopoietins 3 and 4: diverging gene counterparts in mice and humans . Proceedings of the National Academy of Sciences of the United States of America . 96 . 5 . 1904–9 . March 1999 . 10051567 . 26709 . 10.1073/pnas.96.5.1904 . 1999PNAS...96.1904V . free .
• Grosios K, Leek JP, Markham AF, Yancopoulos GD, Jones PF . Assignment of ANGPT4, ANGPT1, and ANGPT2 encoding angiopoietins 4, 1 and 2 to human chromosome bands 20p13, 8q22.3-->q23 and 8p23.1, respectively, by in situ hybridization and radiation hybrid mapping . Cytogenetics and Cell Genetics . 84 . 1–2 . 118–20 . 1999 . 10343124 . 10.1159/000015235 . 40232421 .
• Procopio WN, Pelavin PI, Lee WM, Yeilding NM . Angiopoietin-1 and -2 coiled coil domains mediate distinct homo-oligomerization patterns, but fibrinogen-like domains mediate ligand activity . The Journal of Biological Chemistry . 274 . 42 . 30196–201 . October 1999 . 10514510 . 10.1074/jbc.274.42.30196 . free .
• Kim I, Kim JH, Ryu YS, Jung SH, Nah JJ, Koh GY . Characterization and expression of a novel alternatively spliced human angiopoietin-2 . The Journal of Biological Chemistry . 275 . 24 . 18550–6 . June 2000 . 10766762 . 10.1074/jbc.M910084199 . free .
• Mezquita J, Mezquita P, Montserrat P, Mezquita B, Francone V, Vilagrasa X, Mezquita C . Genomic structure and alternative splicing of chicken angiopoietin-2 . Biochemical and Biophysical Research Communications . 275 . 2 . 643–51 . August 2000 . 10964717 . 10.1006/bbrc.2000.3345 .
• Xu Y, Yu Q . Angiopoietin-1, unlike angiopoietin-2, is incorporated into the extracellular matrix via its linker peptide region . The Journal of Biological Chemistry . 276 . 37 . 34990–8 . September 2001 . 11447223 . 10.1074/jbc.M103661200 . free .
• Acker T, Beck H, Plate KH . Cell type specific expression of vascular endothelial growth factor and angiopoietin-1 and -2 suggests an important role of astrocytes in cerebellar vascularization . Mechanisms of Development . 108 . 1–2 . 45–57 . October 2001 . 11578860 . 10.1016/S0925-4773(01)00471-3 . 18841951 . free .
• Ward EG, Grosios K, Markham AF, Jones PF . Genomic structures of the human angiopoietins show polymorphism in angiopoietin-2 . Cytogenetics and Cell Genetics . 94 . 3–4 . 147–54 . 2002 . 11856872 . 10.1159/000048807 . 22445942 .
• Huang YQ, Li JJ, Hu L, Lee M, Karpatkin S . Thrombin induces increased expression and secretion of angiopoietin-2 from human umbilical vein endothelial cells . Blood . 99 . 5 . 1646–50 . March 2002 . 11861279 . 10.1182/blood.V99.5.1646 . free .
• Hata K, Udagawa J, Fujiwaki R, Nakayama K, Otani H, Miyazaki K . Expression of angiopoietin-1, angiopoietin-2, and Tie2 genes in normal ovary with corpus luteum and in ovarian cancer . Oncology . 62 . 4 . 340–8 . 2002 . 12138242 . 10.1159/000065066 . 40689314 .
• Lin S, Shyu KG, Lee CC, Wang BW, Chang CC, Liu YC, Huang FY, Chang H . Hyperbaric oxygen selectively induces angiopoietin-2 in human umbilical vein endothelial cells . Biochemical and Biophysical Research Communications . 296 . 3 . 710–5 . August 2002 . 12176040 . 10.1016/S0006-291X(02)00924-5 .
• Geva E, Ginzinger DG, Zaloudek CJ, Moore DH, Byrne A, Jaffe RB . Human placental vascular development: vasculogenic and angiogenic (branching and nonbranching) transformation is regulated by vascular endothelial growth factor-A, angiopoietin-1, and angiopoietin-2 . The Journal of Clinical Endocrinology and Metabolism . 87 . 9 . 4213–24 . September 2002 . 12213874 . 10.1210/jc.2002-020195 . free .
• Paradis V, Bièche I, Dargère D, Laurendeau I, Nectoux J, Degott C, Belghiti J, Vidaud M, Bedossa P . A quantitative gene expression study suggests a role for angiopoietins in focal nodular hyperplasia . Gastroenterology . 124 . 3 . 651–9 . March 2003 . 12612904 . 10.1053/gast.2003.50104 . free .

Notes and References

1. Cheung AH, Stewart RJ, Marsden PA . Endothelial Tie2/Tek ligands angiopoietin-1 (ANGPT1) and angiopoietin-2 (ANGPT2): regional localization of the human genes to 8q22.3-q23 and 8p23 . Genomics . 48 . 3 . 389–91 . March 1998 . 9545648 . 10.1006/geno.1997.5207 .
2. Web site: Entrez Gene: ANGPT2 angiopoietin 2.
3. Fiedler U, Krissl T, Koidl S, Weiss C, Koblizek T, Deutsch U, Martiny-Baron G, Marmé D, Augustin HG . Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats . The Journal of Biological Chemistry . 278 . 3 . 1721–7 . January 2003 . 12427764 . 10.1074/jbc.M208550200 . free .
4. Sato A, Iwama A, Takakura N, Nishio H, Yancopoulos GD, Suda T . Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells . . 10 . 8 . 1217–27 . August 1998 . 9723709 . 10.1093/intimm/10.8.1217 . free .
5. Maisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C, Compton D, McClain J, Aldrich TH, Papadopoulos N, Daly TJ, Davis S, Sato TN, Yancopoulos GD . Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis . Science . 277 . 5322 . 55–60 . July 1997 . 9204896 . 10.1126/science.277.5322.55 .