ANAPC7 explained

Anaphase-promoting complex subunit 7 is an enzyme that in humans is encoded by the ANAPC7 gene.^[1] Multiple transcript variants encoding different isoforms have been found for this gene.

Function

This gene encodes a tetratricopeptide repeat containing component of the anaphase-promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators.

Interactions

ANAPC7 has been shown to interact with ANAPC1,^{[2] [3]} ANAPC4,^[2] CDC27^{[2] [4]} and CDC20.^{[2] [5]}

Further reading

• Andersson B, Wentland MA, Ricafrente JY . A "double adaptor" method for improved shotgun library construction . Anal. Biochem. . 236 . 1 . 107–13 . 1996 . 8619474 . 10.1006/abio.1996.0138 . etal.
• Yu W, Andersson B, Worley KC . Large-Scale Concatenation cDNA Sequencing . Genome Res. . 7 . 4 . 353–8 . 1997 . 9110174 . 10.1101/gr.7.4.353. 139146 . etal.
• Yu H, Peters JM, King RW . Identification of a cullin homology region in a subunit of the anaphase-promoting complex . Science . 279 . 5354 . 1219–22 . 1998 . 9469815 . 10.1126/science.279.5354.1219 . 1998Sci...279.1219Y . etal.
• Grossberger R, Gieffers C, Zachariae W . Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex . J. Biol. Chem. . 274 . 20 . 14500–7 . 1999 . 10318877 . 10.1074/jbc.274.20.14500 . etal. free .
• Chan GK, Jablonski SA, Sudakin V . Human Bubr1 Is a Mitotic Checkpoint Kinase That Monitors Cenp-E Functions at Kinetochores and Binds the Cyclosome/APC . J. Cell Biol. . 146 . 5 . 941–54 . 1999 . 10477750 . 10.1083/jcb.146.5.941 . 2169490 . etal.
• Gieffers C, Peters BH, Kramer ER . Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons . Proc. Natl. Acad. Sci. U.S.A. . 96 . 20 . 11317–22 . 1999 . 10500174 . 10.1073/pnas.96.20.11317 . 18031 . 1999PNAS...9611317G . etal. free .
• Gmachl M, Gieffers C, Podtelejnikov AV . The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex . Proc. Natl. Acad. Sci. U.S.A. . 97 . 16 . 8973–8 . 2000 . 10922056 . 10.1073/pnas.97.16.8973 . 16806 . 2000PNAS...97.8973G . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Vodermaier HC, Gieffers C, Maurer-Stroh S . TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1 . Curr. Biol. . 13 . 17 . 1459–68 . 2004 . 12956947 . 10.1016/S0960-9822(03)00581-5 . 5942532 . etal. free . 2003CBio...13.1459V .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Park KH, Choi SE, Eom M, Kang Y . Downregulation of the anaphase-promoting complex (APC)7 in invasive ductal carcinomas of the breast and its clinicopathologic relationships . Breast Cancer Res. . 7 . 2 . R238–47 . 2006 . 15743504 . 10.1186/bcr978 . 1064132 . free .
• Turnell AS, Stewart GS, Grand RJ . The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression . Nature . 438 . 7068 . 690–5 . 2005 . 16319895 . 10.1038/nature04151 . 2005Natur.438..690T . 4432156 . etal.

Notes and References

1. Web site: Entrez Gene: ANAPC7 anaphase promoting complex subunit 7.
2. Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM . TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1 . Curr. Biol. . 13 . 17 . 1459–68 . September 2003 . 12956947 . 10.1016/S0960-9822(03)00581-5 . 5942532 . free . 2003CBio...13.1459V .
3. Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM . Characterization of vertebrate cohesin complexes and their regulation in prophase . J. Cell Biol. . 151 . 4 . 749–62 . November 2000 . 11076961 . 2169443 . 10.1083/jcb.151.4.749 .
4. Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM . The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex . Proc. Natl. Acad. Sci. U.S.A. . 97 . 16 . 8973–8 . August 2000 . 10922056 . 16806 . 10.1073/pnas.97.16.8973 . 2000PNAS...97.8973G . free .
5. Nilsson J, Yekezare M, Minshull J, Pines J . The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction . Nat. Cell Biol. . 10 . 12 . 1411–20 . December 2008 . 18997788 . 2635557 . 10.1038/ncb1799 .