ANAPC1 explained

Anaphase-promoting complex subunit 1 is an enzyme that in humans is encoded by the ANAPC1 gene.^{[1] [2]}

ANAPC1 is one of at least ten subunits of the anaphase-promoting complex (APC), which functions at the metaphase-to-anaphase transition of the cell cycle and is regulated by spindle checkpoint proteins. The APC is an E3 ubiquitin ligase that targets cell cycle regulatory proteins for degradation by the proteasome, thereby allowing progression through the cell cycle (supplied by OMIM).^[2]

Interactions

ANAPC1 has been shown to interact with ANAPC5,^{[3] [4]} ANAPC4,^{[3] [4]} ANAPC2,^{[3] [4]} CDC27^{[3] [4]} and ANAPC7.^{[3] [4]}

Further reading

• Grossberger R, Gieffers C, Zachariae W . Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex. . J. Biol. Chem. . 274 . 20 . 14500–7 . 1999 . 10318877 . 10.1074/jbc.274.20.14500 . etal. free .
• Gieffers C, Peters BH, Kramer ER . Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons. . Proc. Natl. Acad. Sci. U.S.A. . 96 . 20 . 11317–22 . 1999 . 10500174 . 10.1073/pnas.96.20.11317 . 18031 . etal. 1999PNAS...9611317G. free .
• Gmachl M, Gieffers C, Podtelejnikov AV . The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex. . Proc. Natl. Acad. Sci. U.S.A. . 97 . 16 . 8973–8 . 2000 . 10922056 . 10.1073/pnas.97.16.8973 . 16806 . etal. 2000PNAS...97.8973G. free .
• Zur A, Brandeis M . Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis. . EMBO J. . 20 . 4 . 792–801 . 2001 . 11179223 . 10.1093/emboj/20.4.792 . 145417 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal. 2002PNAS...9916899M . free .
• Vodermaier HC, Gieffers C, Maurer-Stroh S . TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1. . Curr. Biol. . 13 . 17 . 1459–68 . 2004 . 12956947 . 10.1016/S0960-9822(03)00581-5 . 5942532 . etal. free . 2003CBio...13.1459V .
• Kraft C, Herzog F, Gieffers C . Mitotic regulation of the human anaphase-promoting complex by phosphorylation. . EMBO J. . 22 . 24 . 6598–609 . 2004 . 14657031 . 10.1093/emboj/cdg627 . 291822 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Beausoleil SA, Jedrychowski M, Schwartz D . Large-scale characterization of HeLa cell nuclear phosphoproteins. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . etal. 2004PNAS..10112130B . free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Nousiainen M, Silljé HH, Sauer G . Phosphoproteome analysis of the human mitotic spindle. . Proc. Natl. Acad. Sci. U.S.A. . 103 . 14 . 5391–6 . 2006 . 16565220 . 10.1073/pnas.0507066103 . 1459365 . etal. 2006PNAS..103.5391N . free .

Notes and References

1. Jorgensen PM, Graslund S, Betz R, Stahl S, Larsson C, Hoog C . Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex . Gene . 262 . 1–2 . 51–9 . February 2001 . 11179667 . 10.1016/S0378-1119(00)00511-4 .
2. Web site: Entrez Gene: ANAPC1 anaphase promoting complex subunit 1.
3. 10.1016/S0960-9822(03)00581-5 . Vodermaier . Hartmut C . Gieffers . Christian . Maurer-Stroh . Sebastian . Eisenhaber . Frank . Peters . Jan-Michael . September 2003 . TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1 . Curr. Biol. . 13 . 17 . 1459–68 . 0960-9822. 12956947 . 5942532 . free . 2003CBio...13.1459V .
4. 10.1083/jcb.151.4.749 . Sumara . I . Vorlaufer E . Gieffers C . Peters B H . Peters J M . November 2000 . Characterization of vertebrate cohesin complexes and their regulation in prophase . J. Cell Biol. . 151 . 4 . 749–62 . 0021-9525. 11076961 . 2169443 .