AMP deaminase 2 explained

AMP deaminase 2 is an enzyme that in humans is encoded by the AMPD2 gene.^{[1] [2]}

High AMPD2 expression levels correlate with poor patient outcome and a proliferative tumor phenotype in undifferentiated pleomorphic sarcoma (UPS). ^[3]

Further reading

• Bausch-Jurken MT, Mahnke-Zizelman DK, Morisaki T, Sabina RL . Molecular cloning of AMP deaminase isoform L. Sequence and bacterial expression of human AMPD2 cDNA. . J. Biol. Chem. . 267 . 31 . 22407–13 . 1992 . 10.1016/S0021-9258(18)41686-9 . 1429593 . free .
• Van den Bergh F, Sabina RL . Characterization of human AMP deaminase 2 (AMPD2) gene expression reveals alternative transcripts encoding variable N-terminal extensions of isoform L . Biochem. J. . 312 . Pt 2. 401–10 . 1996 . 8526848 . 10.1042/bj3120401. 1136276 .
• Mahnke-Zizelman DK, van den Bergh F, Bausch-Jurken MT . Cloning, sequence and characterization of the human AMPD2 gene: evidence for transcriptional regulation by two closely spaced promoters . Biochim. Biophys. Acta . 1308 . 2 . 122–32 . 1996 . 8764830 . 10.1016/0167-4781(96)00089-9. etal.
• Haas AL, Sabina RL . N-terminal extensions of the human AMPD2 polypeptide influence ATP regulation of isoform L . Biochem. Biophys. Res. Commun. . 305 . 2 . 421–7 . 2003 . 12745092 . 10.1016/S0006-291X(03)00787-3 .
• Beausoleil SA, Villén J, Gerber SA . A probability-based approach for high-throughput protein phosphorylation analysis and site localization . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 . etal.
• Olsen JV, Blagoev B, Gnad F . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . etal. free .

Notes and References

1. Mahnke-Zizelman DK, Sabina RL . Cloning of human AMP deaminase isoform E cDNAs. Evidence for a third AMPD gene exhibiting alternatively spliced 5'-exons . J Biol Chem . 267 . 29 . 20866–77 . Nov 1992 . 10.1016/S0021-9258(19)36768-7 . 1400401 . free .
2. Web site: Entrez Gene: AMPD2 adenosine monophosphate deaminase 2 (isoform L).
3. Orth MF, Gerke JS, Knösel T, Altendorf-Hofmann A, Musa J, Alba-Rubio R, Stein S, Hölting TL, Cidrea-Aranaz F, Romero-Pérez L, Dallmayer M, Baldauf MC, Marchetto A, Sannino G, Knott MM, Wehweck F, Ohmura S, Li J, Hakozaki M, Kirchner T, Dandekar T, Butt E, Grünewald TG . 6 . Functional genomics identifies AMPD2 as a new prognostic marker for undifferentiated pleomorphic sarcoma . International Journal of Cancer . September 2018 . 144 . 4 . 859–867 . 30267407 . 10.1002/ijc.31903 . free .