JAML explained

JAML or Junctional Adhesion Molecule-Like, or AMICA1 is a JAM transmembrane protein family member.^{[1] [2]} It is composed of two extracellular immunoglobulin-like domains, a membrane-spanning region, and a cytoplasmic tail involved in activation signaling. A known ligand of JAML is Coxsackie virus and Adenovirus Receptor (CXADR in humans and CAR in mice) which has been shown to localize to the tight junctions of epithelial cells.

JAML-mediated activation of CAR is required for neutrophil extravasation^[3] in addition to other leukocyte/epithelial cell interaction models.

Other members of the JAM family of transmembrane proteins include JAM1, JAM2 and JAM3.

Further reading

• Kimura K . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . Wakamatsu A . Suzuki Y . 3 . Ota . T . Nishikawa . T . Yamashita . R . Yamamoto . J . Sekine . M . Tsuritani . K .
• Zen K . Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial coxsackie and adenovirus receptor and a junctional adhesion molecule-like protein on neutrophils . Mol. Biol. Cell . 16 . 6 . 2694–703 . 2005 . 15800062 . 10.1091/mbc.E05-01-0036 . 1142417 . Liu Y . McCall IC . 3 . Wu . T . Lee . W . Babbin . BA . Nusrat . A . Parkos . CA .
• Zhang Z, Henzel WJ . Signal peptide prediction based on analysis of experimentally verified cleavage sites . Protein Sci. . 13 . 10 . 2819–24 . 2005 . 15340161 . 10.1110/ps.04682504 . 2286551 .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Moog-Lutz C . JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells . Blood . 102 . 9 . 3371–8 . 2004 . 12869515 . 10.1182/blood-2002-11-3462 . Cavé-Riant F . Guibal FC . 3 . Breau . MA . Di Gioia . Y . Couraud . PO . Cayre . YE . Bourdoulous . S . Lutz . PG . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Dias Neto E . Shotgun sequencing of the human transcriptome with ORF expressed sequence tags . Proc. Natl. Acad. Sci. U.S.A. . 97 . 7 . 3491–6 . 2000 . 10737800 . 10.1073/pnas.97.7.3491 . 16267 . Correa RG . Verjovski-Almeida S . 3 . Briones . MR . Nagai . MA . Da Silva Jr. . W . Zago . MA . Bordin . S . Costa . FF . 2000PNAS...97.3491D . free .

Notes and References

1. Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment . Genome Res . 13 . 10 . 2265–70 . Oct 2003 . 12975309 . 403697 . 10.1101/gr.1293003 .
2. Web site: Entrez Gene: AMICA1 adhesion molecule, interacts with CXADR antigen 1.
3. 2694–703 . 10.1091/mbc.E05-01-0036 . Neutrophil Migration across Tight Junctions is Mediated by Adhesive Interactions between Epithelial Coxsackie and Adenovirus Receptor and a Junctional Adhesion Molecule-like Protein on Neutrophils . 2005 . Zen . K. . Molecular Biology of the Cell . 16 . 6 . 15800062 . Liu . Y . McCall . IC . Wu . T . Lee . W . Babbin . BA . Nusrat . A . Parkos . CA . 1142417.