AMG-41 explained

AMG-41 (part of the AM cannabinoid series) is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8-THC substituted with a cyclopropyl group on the C1'-position of the C3-alkyl side chain. AMG-41 is a potent agonist at both CB1 and CB2, with a Ki of 0.44 nM at CB1 vs 0.86 nM at CB2.[1] [2] [3]

See also

Notes and References

  1. Papahatjis DP, Nikas SP, Andreou T, Makriyannis A . Novel 1',1'-chain substituted Delta(8)-tetrahydrocannabinols . Bioorganic & Medicinal Chemistry Letters . 12 . 24 . 3583–6 . December 2002 . 12443781 . 10.1016/s0960-894x(02)00785-0 .
  2. Papahatjis DP, Nikas SP, Kourouli T, Chari R, Xu W, Pertwee RG, Makriyannis A . Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1' . Journal of Medicinal Chemistry . 46 . 15 . 3221–9 . July 2003 . 12852753 . 10.1021/jm020558c .
  3. Papahatjis DP, Nahmias VR, Nikas SP, Andreou T, Alapafuja SO, Tsotinis A, Guo J, Fan P, Makriyannis A . 6 . C1'-cycloalkyl side chain pharmacophore in tetrahydrocannabinols . Journal of Medicinal Chemistry . 50 . 17 . 4048–60 . August 2007 . 17672444 . 10.1021/jm070121a .

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