AMG-36 explained

AMG-36 (part of the AM cannabinoid series) is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8-THC substituted with a cyclopentane group on the 3-position side chain. AMG-36 is a potent agonist at both CB1 and CB2 with moderate selectivity for CB1, with a Ki of 0.45 nM at CB1 vs 1.92 nM at CB2.[1] [2]

See also

Notes and References

  1. Papahatjis DP, Nikas SP, Kourouli T, Chari R, Xu W, Pertwee RG, Makriyannis A . Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1' . Journal of Medicinal Chemistry . 46 . 15 . 3221–9 . July 2003 . 12852753 . 10.1021/jm020558c .
  2. Papahatjis DP, Nahmias VR, Nikas SP, Andreou T, Alapafuja SO, Tsotinis A, Guo J, Fan P, Makriyannis A . 6 . C1'-cycloalkyl side chain pharmacophore in tetrahydrocannabinols . Journal of Medicinal Chemistry . 50 . 17 . 4048–60 . August 2007 . 17672444 . 10.1021/jm070121a .

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