AMFR explained

Autocrine motility factor receptor, isoform 2 is a protein that in humans is encoded by the AMFR gene.^{[1] [2]}

Autocrine motility factor is a tumor motility-stimulating protein secreted by tumor cells. The protein encoded by this gene is a glycosylated transmembrane protein and a receptor for autocrine motility factor. The receptor, which shows some sequence similarity to tumor protein p53, is localized to the leading and trailing edges of carcinoma cells.^[2]

Interactions

AMFR has been shown to interact with Valosin-containing protein.^{[3] [4]}

Further reading

• Huang B, Xie Y, Raz A . Identification of an upstream region that controls the transcription of the human autocrine motility factor receptor. . Biochem. Biophys. Res. Commun. . 212 . 3 . 727–42 . 1995 . 7626106 . 10.1006/bbrc.1995.2031 .
• Hillier LD, Lennon G, Becker M . Generation and analysis of 280,000 human expressed sequence tags. . Genome Res. . 6 . 9 . 807–28 . 1997 . 8889549 . 10.1101/gr.6.9.807 . etal. free .
• Shimizu K, Tani M, Watanabe H . The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein. . FEBS Lett. . 456 . 2 . 295–300 . 1999 . 10456327 . 10.1016/S0014-5793(99)00966-7 . 39270348 . etal. free .
• Fang S, Ferrone M, Yang C . The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum. . Proc. Natl. Acad. Sci. U.S.A. . 98 . 25 . 14422–7 . 2002 . 11724934 . 10.1073/pnas.251401598 . 64697 . etal. 2001PNAS...9814422F . free .
• Luo Y, Long JM, Lu C . A link between maze learning and hippocampal expression of neuroleukin and its receptor gp78. . J. Neurochem. . 80 . 2 . 354–61 . 2002 . 11902125 . 10.1046/j.0022-3042.2001.00707.x . 29857457 . etal. free .
• Tímár J, Rásó E, Döme B . Expression and function of the AMF receptor by human melanoma in experimental and clinical systems. . Clin. Exp. Metastasis . 19 . 3 . 225–32 . 2002 . 12067203 . 10.1023/A:1015595708241 . 453423 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal. 2002PNAS...9916899M . free .
• Liang JS, Kim T, Fang S . Overexpression of the tumor autocrine motility factor receptor Gp78, a ubiquitin protein ligase, results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in HepG2 cells. . J. Biol. Chem. . 278 . 26 . 23984–8 . 2003 . 12670940 . 10.1074/jbc.M302683200 . etal. free .
• Takanami I, Takeuchi K . Autocrine motility factor-receptor gene expression in lung cancer. . Jpn. J. Thorac. Cardiovasc. Surg. . 51 . 8 . 368–73 . 2003 . 12962414 . 10.1007/BF02719469 .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Registre M, Goetz JG, St Pierre P . The gene product of the gp78/AMFR ubiquitin E3 ligase cDNA is selectively recognized by the 3F3A antibody within a subdomain of the endoplasmic reticulum. . Biochem. Biophys. Res. Commun. . 320 . 4 . 1316–22 . 2004 . 15303277 . 10.1016/j.bbrc.2004.06.089 . etal.
• Zhong X, Shen Y, Ballar P . AAA ATPase p97/valosin-containing protein interacts with gp78, a ubiquitin ligase for endoplasmic reticulum-associated degradation. . J. Biol. Chem. . 279 . 44 . 45676–84 . 2004 . 15331598 . 10.1074/jbc.M409034200 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Song BL, Sever N, DeBose-Boyd RA . Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase. . Mol. Cell . 19 . 6 . 829–40 . 2005 . 16168377 . 10.1016/j.molcel.2005.08.009 . free .
• Kaynak K, Kara M, Oz B . Autocrine motility factor receptor expression implies an unfavourable prognosis in resected stage I pulmonary adenocarcinomas. . Acta Chir. Belg. . 105 . 4 . 378–82 . 2006 . 16184720 . 10.1080/00015458.2005.11679740. 3032480 . etal.
• Ye Y, Shibata Y, Kikkert M . Inaugural Article: Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane. . Proc. Natl. Acad. Sci. U.S.A. . 102 . 40 . 14132–8 . 2006 . 16186510 . 10.1073/pnas.0505006102 . 1242302 . etal. 2005PNAS..10214132Y . free .
• Chen B, Mariano J, Tsai YC . The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding site. . Proc. Natl. Acad. Sci. U.S.A. . 103 . 2 . 341–6 . 2006 . 16407162 . 10.1073/pnas.0506618103 . 1326157 . etal. 2006PNAS..103..341C . free .
• Haga A, Tanaka N, Funasaka T . The autocrine motility factor (AMF) and AMF-receptor combination needs sugar chain recognition ability and interaction using the C-terminal region of AMF. . J. Mol. Biol. . 358 . 3 . 741–53 . 2006 . 16563432 . 10.1016/j.jmb.2006.02.046 . etal.
• Shen Y, Ballar P, Fang S . Ubiquitin ligase gp78 increases solubility and facilitates degradation of the Z variant of alpha-1-antitrypsin. . Biochem. Biophys. Res. Commun. . 349 . 4 . 1285–93 . 2006 . 16979136 . 10.1016/j.bbrc.2006.08.173 .

Notes and References

1. Watanabe H, Carmi P, Hogan V, Raz T, Silletti S, Nabi IR, Raz A . Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor . J Biol Chem . 266 . 20 . 13442–8 . Aug 1991 . 10.1016/S0021-9258(18)98859-9 . 1649192 . free .
2. Web site: Entrez Gene: AMFR autocrine motility factor receptor.
3. Zhong . Xiaoyan . Shen Yuxian . Ballar Petek . Apostolou Andria . Agami Reuven . Fang Shengyun . Oct 2004 . AAA ATPase p97/valosin-containing protein interacts with gp78, a ubiquitin ligase for endoplasmic reticulum-associated degradation . J. Biol. Chem. . 279 . 44 . 45676–84 . United States. 0021-9258. 15331598 . 10.1074/jbc.M409034200 . free .
4. Lee . Joon No . Zhang Xiangyu . Feramisco Jamison D . Gong Yi . Ye Jin . Nov 2008 . Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step . J. Biol. Chem. . 283 . 48 . 33772–83 . United States. 0021-9258. 18835813 . 10.1074/jbc.M806108200 . 2586246 . free .