AM-905 explained

AM-905 (part of the AM cannabinoid series) is an analgesic drug which is a cannabinoid agonist. It is conformationally restricted by virtue of the double bond on its side chain, leading an increased affinity for and selectivity between CB₁ and CB₂ receptors.^[1] It is a potent and reasonably selective agonist for the CB₁ cannabinoid receptor, with a K_i of 1.2 nM at CB₁ and 5.3 nM at CB₂.^[2]

See also

• 1,2-Didehydro-3-oxo-THCO
• AM-906 - The corresponding Z or cis isomer
• HU-243 - Double bond replaced by geminal methyls for Thorpe–Ingold effect

Notes and References

1. Busch-Petersen J, Hill WA, Fan P, Khanolkar A, Xie XQ, Tius MA, Makriyannis A . Unsaturated side chain beta-11-hydroxyhexahydrocannabinol analogs . Journal of Medicinal Chemistry . 39 . 19 . 3790–6 . September 1996 . 8809166 . 10.1021/jm950934b . Alexandros Makriyannis .
2. Papahatjis DP, Kourouli T, Abadji V, Goutopoulos A, Makriyannis A . Pharmacophoric requirements for cannabinoid side chains: multiple bond and C1'-substituted delta 8-tetrahydrocannabinols . Journal of Medicinal Chemistry . 41 . 7 . 1195–200 . March 1998 . 9544219 . 10.1021/jm970277i .