AM-679 (FLAP inhibitor) explained

AM-679 is a drug which acts as a selective inhibitor of 5-Lipoxygenase-activating protein (FLAP). This protein is involved in the production of cysteinyl leukotrienes which are involved in inflammation, and AM-679 has anti-inflammatory effects in animal studies.^{[1] [2]}

Notes and References

1. Stock N, Baccei C, Bain G, Broadhead A, Chapman C, Darlington J, King C, Lee C, Li Y, Lorrain DS, Prodanovich P, Rong H, Santini A, Zunic J, Evans JF, Hutchinson JH, Prasit P . 6 . 5-Lipoxygenase-activating protein inhibitors. Part 2: 3--2,2-dimethyl-propionic acid (AM679)--a potent FLAP inhibitor . Bioorganic & Medicinal Chemistry Letters . 20 . 1 . 213–217 . January 2010 . 19914828 . 10.1016/j.bmcl.2009.10.131 .
2. Musiyenko A, Correa L, Stock N, Hutchinson JH, Lorrain DS, Bain G, Evans JF, Barik S . 6 . A novel 5-lipoxygenase-activating protein inhibitor, AM679, reduces inflammation in the respiratory syncytial virus-infected mouse eye . Clinical and Vaccine Immunology . 16 . 11 . 1654–1659 . November 2009 . 19759251 . 2772391 . 10.1128/CVI.00220-09 .