AM-411 explained

AM-411 (part of the AM cannabinoid series) is an analgesic drug that is a cannabinoid agonist. It is a derivative of Δ8-THC substituted with an adamantyl group at the 3-position, demonstrating that the binding pocket for the alkyl chain at this position can accommodate significant bulk.

AM-411 is a potent and fairly selective CB₁ full agonist with a K_i of 6.80 nM, but is still also a moderately potent CB₂ agonist with a K_i of 52.0 nM.^[1] It produces similar effects to other cannabinoid agonists such as analgesia, sedation, and anxiolysis.^{[2] [3]}

See also

• AM-087
• AM-1248
• KM-233

Notes and References

1. Lu D, Meng Z, Thakur GA, Fan P, Steed J, Tartal CL, Hurst DP, Reggio PH, Deschamps JR, Parrish DA, George C, Järbe TU, Lamb RJ, Makriyannis A . 6 . Adamantyl cannabinoids: a novel class of cannabinergic ligands . Journal of Medicinal Chemistry . 48 . 14 . 4576–85 . July 2005 . 15999995 . 10.1021/jm058175c .
2. Järbe TU, DiPatrizio NV, Lu D, Makriyannis A . (−)-Adamantyl-delta8-tetrahydrocannabinol (AM-411), a selective cannabinoid CB1 receptor agonist: effects on open-field behaviors and antagonism by SR-141716 in rats . Behavioural Pharmacology . 15 . 7 . 517–21 . November 2004 . 15472574 . 10.1097/00008877-200411000-00008 . 23889056 .
3. McLaughlin PJ, Lu D, Winston KM, Thakur G, Swezey LA, Makriyannis A, Salamone JD . Behavioral effects of the novel cannabinoid full agonist AM 411 . Pharmacology, Biochemistry, and Behavior . 81 . 1 . 78–88 . May 2005 . 15894067 . 10.1016/j.pbb.2005.02.005 . 806517 .