AM-0902 explained

AM-0902 is a drug which acts as a potent and selective antagonist for the TRPA1 receptor, and has analgesic and antiinflammatory effects.[1] [2]

Notes and References

  1. Schenkel LB, Olivieri PR, Boezio AA, Deak HL, Emkey R, Graceffa RF, Gunaydin H, Guzman-Perez A, Lee JH, Teffera Y, Wang W, Youngblood BD, Yu VL, Zhang M, Gavva NR, Lehto SG, Geuns-Meyer S . 6 . Optimization of a Novel Quinazolinone-Based Series of Transient Receptor Potential A1 (TRPA1) Antagonists Demonstrating Potent in Vivo Activity . Journal of Medicinal Chemistry . 59 . 6 . 2794–809 . March 2016 . 26942860 . 10.1021/acs.jmedchem.6b00039 .
  2. Huang Y, Chen SR, Chen H, Pan HL . Endogenous transient receptor potential ankyrin 1 and vanilloid 1 activity potentiates glutamatergic input to spinal lamina I neurons in inflammatory pain . Journal of Neurochemistry . 149 . 3 . 381–398 . May 2019 . 30716174 . 10.1111/jnc.14677 . 6483867 .

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