AM-087 explained

AM-087 (part of the AM cannabinoid series) is an analgesic drug which acts as a cannabinoid agonist.[1] It is a derivative of Δ8-THC, substituted on the 3-position side chain. AM-087 is a potent CB1 agonist with a Ki of 0.43 nM, making it around 100 times more potent than THC itself. This is most likely due to the bulky bromine substituent on the side chain.[2]

See also

Notes and References

  1. Martin BR, Compton DR, Semus SF, Lin S, Marciniak G, Grzybowska J, Charalambous A, Makriyannis A . 6 . Pharmacological evaluation of iodo and nitro analogs of Δ8-THC and Δ9-THC . Pharmacology, Biochemistry, and Behavior . 46 . 2 . 295–301 . October 1993 . 8265683 . 10.1016/0091-3057(93)90356-X . 140209578 .
  2. Charalambous A, Lin S, Marciniak G, Banijamali A, Friend FL, Compton DR, Martin BR, Makriyannis A . 6 . Pharmacological evaluation of halogenated delta 8-THC analogs . Pharmacology, Biochemistry, and Behavior . 40 . 3 . 509–12 . November 1991 . 1666915 . 10.1016/0091-3057(91)90355-6 . 140209927 .

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