ALS2CR2 explained

STE20-related kinase adapter protein beta is an enzyme that in humans is encoded by the STRADB gene.^{[1] [2] [3]}

This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene.

Interactions

ALS2CR2 has been shown to interact with XIAP.^[4]

Further reading

• Alessi DR, Sakamoto K, Bayascas JR . LKB1-dependent signaling pathways . Annual Review of Biochemistry . 75 . 137–63 . 2007 . 16756488 . 10.1146/annurev.biochem.75.103004.142702 .
• Boudeau J, Miranda-Saavedra D, Barton GJ, Alessi DR . Emerging roles of pseudokinases . Trends in Cell Biology . 16 . 9 . 443–52 . September 2006 . 16879967 . 10.1016/j.tcb.2006.07.003 .
• Sanna MG, da Silva Correia J, Luo Y, Chuang B, Paulson LM, Nguyen B, Deveraux QL, Ulevitch RJ . ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis . The Journal of Biological Chemistry . 277 . 34 . 30454–62 . August 2002 . 12048196 . 10.1074/jbc.M203312200 . free .
• Nishigaki K, Thompson D, Yugawa T, Rulli K, Hanson C, Cmarik J, Gutkind JS, Teramoto H, Ruscetti S . Identification and characterization of a novel Ste20/germinal center kinase-related kinase, polyploidy-associated protein kinase . The Journal of Biological Chemistry . 278 . 15 . 13520–30 . April 2003 . 12574163 . 10.1074/jbc.M208601200 . free .
• Boudeau J, Baas AF, Deak M, Morrice NA, Kieloch A, Schutkowski M, Prescott AR, Clevers HC, Alessi DR . MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm . The EMBO Journal . 22 . 19 . 5102–14 . October 2003 . 14517248 . 204473 . 10.1093/emboj/cdg490 .
• Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G . Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network . The Journal of Biological Chemistry . 279 . 13 . 12804–11 . March 2004 . 14676191 . 10.1074/jbc.M312171200 . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . October 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Hadano S, Yanagisawa Y, Skaug J, Fichter K, Nasir J, Martindale D, Koop BF, Scherer SW, Nicholson DW, Rouleau GA, Ikeda J, Hayden MR . Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2 . Genomics . 71 . 2 . 200–13 . January 2001 . 11161814 . 10.1006/geno.2000.6392 .
2. Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Mäkelä TP, Alessi DR, Hardie DG . Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade . Journal of Biology . 2 . 4 . 28 . Jul 2004 . 14511394 . 333410 . 10.1186/1475-4924-2-28 . free .
3. Web site: Entrez Gene: ALS2CR2 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2.
4. Sanna MG, da Silva Correia J, Luo Y, Chuang B, Paulson LM, Nguyen B, Deveraux QL, Ulevitch RJ . ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis . The Journal of Biological Chemistry . 277 . 34 . 30454–62 . August 2002 . 12048196 . 10.1074/jbc.M203312200 . free .