ALG13 explained

UDP-N-acetylglucosamine transferase subunit ALG13 homolog, also known as asparagine-linked glycosylation 13 homolog, is an enzyme that in humans is encoded by the ALG13 gene.^{[1] [2]}

Function

The protein encoded by this gene is a subunit of a bipartite UDP-N-acetylglucosamine transferase. It heterodimerizes with asparagine-linked glycosylation 14 (ALG14) homolog to form a functional UDP-GlcNAc glycosyltransferase that catalyzes the second sugar addition of the highly conserved oligosaccharide precursor in endoplasmic reticulum N-linked glycosylation.^{[1] [3]}

See also

• Congenital disorder of glycosylation

Further reading

• Ross MT, Grafham DV, Coffey AJ . The DNA sequence of the human X chromosome . Nature . 434 . 7031 . 325–37 . 2005 . 15772651 . 10.1038/nature03440 . 2665286. 2005Natur.434..325R . etal.
• Mizuochi T, Matthews TJ, Kato M . Diversity of oligosaccharide structures on the envelope glycoprotein gp 120 of human immunodeficiency virus 1 from the lymphoblastoid cell line H9. Presence of complex-type oligosaccharides with bisecting N-acetylglucosamine residues . J. Biol. Chem. . 265 . 15 . 8519–24 . 1990 . 10.1016/S0021-9258(19)38919-7 . 2341393 . etal. free .
• Shimizu H, Tsuchie H, Honma H . Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteins . Jpn. J. Med. Sci. Biol. . 43 . 3 . 75–87 . 1990 . 2283726 . 10.7883/yoken1952.43.75. etal. free .
• Yeh JC, Seals JR, Murphy CI . Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system . Biochemistry . 32 . 41 . 11087–99 . 1993 . 8218172 . 10.1021/bi00092a019. etal.
• Kimura K, Wakamatsu A, Suzuki Y . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129. etal.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3. etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928. etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Oh JH, Yang JO, Hahn Y . Transcriptome analysis of human gastric cancer . Mamm. Genome . 16 . 12 . 942–54 . 2005 . 16341674 . 10.1007/s00335-005-0075-2 . 69278 . etal.
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241. 2002PNAS...9916899M . etal. free .
• Epplen C, Epplen JT . Expression of (cac)n/(gtg)n simple repetitive sequences in mRNA of human lymphocytes . Hum. Genet. . 93 . 1 . 35–41 . 1994 . 7505766 . 10.1007/BF00218910. 22998633 .
• Venter JC, Adams MD, Myers EW . The sequence of the human genome . Science . 291 . 5507 . 1304–51 . 2001 . 11181995 . 10.1126/science.1058040 . 2001Sci...291.1304V . etal.
• Kozarsky K, Penman M, Basiripour L . Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein . J. Acquir. Immune Defic. Syndr. . 2 . 2 . 163–9 . 1989 . 2649653 . etal.

Notes and References

1. Web site: Entrez Gene: asparagine-linked glycosylation 13 homolog (S. cerevisiae).
2. Gao XD, Tachikawa H, Sato T, Jigami Y, Dean N . Alg14 recruits Alg13 to the cytoplasmic face of the endoplasmic reticulum to form a novel bipartite UDP-N-acetylglucosamine transferase required for the second step of N-linked glycosylation . J. Biol. Chem. . 280 . 43 . 36254–62 . October 2005 . 16100110 . 10.1074/jbc.M507569200 . free .
3. Averbeck N, Keppler-Ross S, Dean N . Membrane topology of the Alg14 endoplasmic reticulum UDP-GlcNAc transferase subunit . J. Biol. Chem. . 282 . 40 . 29081–8 . October 2007 . 17686769 . 10.1074/jbc.M704410200 . free .