ALDH1L1 explained

10-formyltetrahydrofolate dehydrogenase is an enzyme that in humans is encoded by the ALDH1L1 gene.^[1]

The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family and is responsible for formate oxidation in vivo. Deficiencies in this gene can result in an accumulation of formate and subsequent methanol poisoning.^[1]

Further reading

• Lee KM, Lan Q, Kricker A . One-carbon metabolism gene polymorphisms and risk of non-Hodgkin lymphoma in Australia. . Hum. Genet. . 122 . 5 . 525–33 . 2007. 17891500 . 10.1007/s00439-007-0431-2 . 21487646 . etal.
• Stevens VL, McCullough ML, Pavluck AL . Association of polymorphisms in one-carbon metabolism genes and postmenopausal breast cancer incidence. . Cancer Epidemiol. Biomarkers Prev. . 16 . 6 . 1140–7 . 2007 . 17548676 . 10.1158/1055-9965.EPI-06-1037 . etal. 25945965 .
• Lim U, Wang SS, Hartge P . Gene-nutrient interactions among determinants of folate and one-carbon metabolism on the risk of non-Hodgkin lymphoma: NCI-SEER case-control study. . Blood . 109 . 7 . 3050–9 . 2007 . 17119116 . 10.1182/blood-2006-07-034330 . 1852210 . etal.
• Oleinik NV, Krupenko SA . Ectopic expression of 10-formyltetrahydrofolate dehydrogenase in A549 cells induces G1 cell cycle arrest and apoptosis. . Mol. Cancer Res. . 1 . 8 . 577–88 . 2004 . 12805405 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Krupenko SA, Oleinik NV . 10-formyltetrahydrofolate dehydrogenase, one of the major folate enzymes, is down-regulated in tumor tissues and possesses suppressor effects on cancer cells. . Cell Growth Differ. . 13 . 5 . 227–36 . 2002 . 12065246 .
• Hong M, Lee Y, Kim JW . Isolation and characterization of cDNA clone for human liver 10-formyltetrahydrofolate dehydrogenase. . Biochem. Mol. Biol. Int. . 47 . 3 . 407–15 . 1999 . 10204077 . 10.1080/15216549900201433. 10950424 . etal. free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Champion KM, Cook RJ, Tollaksen SL, Giometti CS . Identification of a heritable deficiency of the folate-dependent enzyme 10-formyltetrahydrofolate dehydrogenase in mice . Proc. Natl. Acad. Sci. U.S.A. . 91 . 24 . 11338–42 . 1994 . 7972060 . 10.1073/pnas.91.24.11338 . 45226 . 1994PNAS...9111338C . free .
• Johlin FC, Swain E, Smith C, Tephly TR . Studies on the mechanism of methanol poisoning: purification and comparison of rat and human liver 10-formyltetrahydrofolate dehydrogenase . Mol. Pharmacol. . 35 . 6 . 745–50 . 1989 . 2733692 .

Notes and References

1. Web site: Entrez Gene: ALDH1L1 aldehyde dehydrogenase 1 family, member L1.