ALC-0159 explained

ALC-0159 is a PEG/lipid conjugate (i.e. PEGylated lipid), specifically, it is the N,N-dimyristylamide of 2-hydroxyacetic acid, O-pegylated to a PEG chain mass of about 2 kilodaltons (corresponding to about 45-46 ethylene oxide units per molecule of N,N-dimyristyl hydroxyacetamide). It is a non-ionic surfactant by its nature. It has been deployed in the Pfizer-BioNTech SARS-CoV-2 mRNA vaccine (0.05 mg per dose)^[1] that contains the active ingredient tozinameran.^[2]

See also

Pfizer–BioNTech COVID-19 vaccine nanoparticle ingredients

• ALC-0315
• 1,2-distearoyl-sn-glycero-3-phosphocholine
• Cholesterol

Others

• Polyethoxylated tallow amine

References

• Assessment report, Comirnaty, Common name: COVID-19 mRNA vaccine (nucleoside-modified); Procedure No. EMEA/H/C/005735/0000 - gives structural formula for the compound (p. 24)

Notes and References

1. Schoenmaker. Linde. Witzigmann. Dominik. Kulkarni. Jayesh A.. Verbeke. Rein. Kersten. Gideon. Jiskoot. Wim. Crommelin. Daan J. A.. 2021-05-15. mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability. International Journal of Pharmaceutics. en. 601. 120586. 10.1016/j.ijpharm.2021.120586. 33839230 . 8032477 . 0378-5173. free.
2. News: Public Assessment Report Authorisation for Temporary Supply COVID-19 mRNA Vaccine BNT162b2 (BNT162b2 RNA) concentrate for solution for injection . Regulation 174 . MHRA . 15 December 2020.