AL-37350A explained

AL-37350A (4,5-DHP-AMT) is a tricyclic tryptamine derivative which acts as a potent and selective agonist for the serotonin receptor 5-HT_2A, with a Ki of 2.0 nM, and moderate selectivity over the related 5-HT_2B and 5-HT_2C receptors. It has been shown to have ocular hypotensive activity in animal models, suggesting it may be useful for the treatment of glaucoma.^[1]

See also

• Ramelteon
• AL-38022A
• CP-132,484
• 4,5-DHP-DMT

Notes and References

1. May JA, Chen HH, Rusinko A, Lynch VM, Sharif NA, McLaughlin MA . A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole . Journal of Medicinal Chemistry . 46 . 19 . 4188–95 . September 2003 . 12954071 . 10.1021/jm030205t . 10.1.1.688.6169 .