AKT1S1 explained

Proline-rich AKT1 substrate 1 (PRAS) is a protein that in humans is encoded by the AKT1S1 gene.^{[1] [2]}

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . Jan 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . Oct 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Saito A, Narasimhan P, Hayashi T, Okuno S, Ferrand-Drake M, Chan PH . Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: relationships with nerve growth factor . The Journal of Neuroscience . 24 . 7 . 1584–93 . Feb 2004 . 14973226 . 6730448 . 10.1523/JNEUROSCI.5209-03.2004 . free .
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proceedings of the National Academy of Sciences of the United States of America . 101 . 33 . 12130–5 . Aug 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .
• Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T . Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization . Current Biology . 14 . 16 . 1436–50 . Aug 2004 . 15324660 . 10.1016/j.cub.2004.07.051 . free . 2004CBio...14.1436J .
• Huang B, Porter G . Expression of proline-rich Akt-substrate PRAS40 in cell survival pathway and carcinogenesis . Acta Pharmacologica Sinica . 26 . 10 . 1253–8 . Oct 2005 . 16174443 . 10.1111/j.1745-7254.2005.00184.x . free .
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Research . 16 . 1 . 55–65 . Jan 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . Nov 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . free .
• Vander Haar E, Lee SI, Bandhakavi S, Griffin TJ, Kim DH . Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40 . Nature Cell Biology . 9 . 3 . 316–23 . Mar 2007 . 17277771 . 10.1038/ncb1547 . 12827916 .
• Sancak Y, Thoreen CC, Peterson TR, Lindquist RA, Kang SA, Spooner E, Carr SA, Sabatini DM . PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase . Molecular Cell . 25 . 6 . 903–15 . Mar 2007 . 17386266 . 10.1016/j.molcel.2007.03.003 . free .
• Wang L, Harris TE, Roth RA, Lawrence JC . PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding . The Journal of Biological Chemistry . 282 . 27 . 20036–44 . Jul 2007 . 17510057 . 10.1074/jbc.M702376200 . free.
• Fonseca BD, Smith EM, Lee VH, MacKintosh C, Proud CG . PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex . The Journal of Biological Chemistry . 282 . 34 . 24514–24 . Aug 2007 . 17604271 . 10.1074/jbc.M704406200 . free .

Notes and References

1. Kovacina KS, Park GY, Bae SS, Guzzetta AW, Schaefer E, Birnbaum MJ, Roth RA . Identification of a proline-rich Akt substrate as a 14-3-3 binding partner . The Journal of Biological Chemistry . 278 . 12 . 10189–94 . Mar 2003 . 12524439 . 10.1074/jbc.M210837200 . free .
2. Web site: Entrez Gene: AKT1S1 AKT1 substrate 1 (proline-rich).