AKR1B10 explained

Aldo-keto reductase family 1 member B10 is an enzyme that in humans is encoded by the AKR1B10 gene.^{[1] [2] [3]}

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis.^[3]

Further reading

• Scuric Z, Stain SC, Anderson WF, Hwang JJ . New member of aldose reductase family proteins overexpressed in human hepatocellular carcinoma . Hepatology . 27 . 4 . 943–50 . April 1998 . 9537432 . 10.1002/hep.510270408 . 23740299 . free .
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA . 6 . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proceedings of the National Academy of Sciences of the United States of America . 99 . 26 . 16899–903 . December 2002 . 12477932 . 139241 . 10.1073/pnas.242603899 . 2002PNAS...9916899M . free .
• Crosas B, Hyndman DJ, Gallego O, Martras S, Parés X, Flynn TG, Farrés J . Human aldose reductase and human small intestine aldose reductase are efficient retinal reductases: consequences for retinoid metabolism . The Biochemical Journal . 373 . Pt 3 . 973–9 . August 2003 . 12732097 . 1223539 . 10.1042/BJ20021818 .
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J . 6 . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Research . 14 . 10B . 2121–7 . October 2004 . 15489334 . 528928 . 10.1101/gr.2596504 .
• Petrovic MG, Peterlin B, Hawlina M, Petrovic D . Aldose reductase (AC)n gene polymorphism and susceptibility to diabetic retinopathy in Type 2 diabetes in Caucasians . Journal of Diabetes and Its Complications . 19 . 2 . 70–3 . 2005 . 15745835 . 10.1016/j.jdiacomp.2004.08.004 .
• Kang ES, Kim HJ, Paek KS, Jang HS, Chang KC, Lee JH, Nishinaka T, Yabe-Nishimura C, Seo HG . 6 . Phorbol ester up-regulates aldose reductase expression in A549 cells: a potential role for aldose reductase in cell cycle modulation . Cellular and Molecular Life Sciences . 62 . 10 . 1146–55 . May 2005 . 15928807 . 10.1007/s00018-005-5024-4 . 13502923 .
• Lee YS, Paek KS, Kang ES, Jang HS, Kim HJ, Kang YJ, Kim JH, Lee HT, Lee JH, Chang KC, Nishinaka T, Seo HG . 6 . Involvement of nuclear factor kappaB in up-regulation of aldose reductase gene expression by 12-O-tetradecanoylphorbol-13-acetate in HeLa cells . The International Journal of Biochemistry & Cell Biology . 37 . 11 . 2297–309 . November 2005 . 15936242 . 10.1016/j.biocel.2005.04.016 .
• Vikramadithyan RK, Hu Y, Noh HL, Liang CP, Hallam K, Tall AR, Ramasamy R, Goldberg IJ . 6 . Human aldose reductase expression accelerates diabetic atherosclerosis in transgenic mice . The Journal of Clinical Investigation . 115 . 9 . 2434–43 . September 2005 . 16127462 . 1190371 . 10.1172/JCI24819 .
• Hazemann I, Dauvergne MT, Blakeley MP, Meilleur F, Haertlein M, Van Dorsselaer A, Mitschler A, Myles DA, Podjarny A . 6 . High-resolution neutron protein crystallography with radically small crystal volumes: application of perdeuteration to human aldose reductase . Acta Crystallographica. Section D, Biological Crystallography . 61 . Pt 10 . 1413–7 . October 2005 . 16204895 . 10.1107/S0907444905024285 . 2005AcCrD..61.1413H .
• Mashkova TD, Oparina NI, Zinov'eva OL, Kropotova ES, Dubovaia VI, Poltaraus AB, Fridman MV, Kopantsev EP, Vinogradova TV, Zinov'eva MV, Laktionov KK, Kasymova OT, Zborovskaia IB, Sverdlov ED, Kiselev LL . 6 . [Transcription TIMP3, DAPk1 and AKR1B10 genes in squamous cell lung cancer] . Molekuliarnaia Biologiia . 40 . 6 . 1047–54 . 2007 . 17209433 . 10.1134/s0026893306060148 . 39287274 .
• Tammali R, Ramana KV, Srivastava SK . Aldose reductase regulates TNF-alpha-induced PGE2 production in human colon cancer cells . Cancer Letters . 252 . 2 . 299–306 . July 2007 . 17300864 . 1945127 . 10.1016/j.canlet.2007.01.001 .
• Yan R, Zu X, Ma J, Liu Z, Adeyanju M, Cao D . Aldo-keto reductase family 1 B10 gene silencing results in growth inhibition of colorectal cancer cells: Implication for cancer intervention . International Journal of Cancer . 121 . 10 . 2301–6 . November 2007 . 17597105 . 10.1002/ijc.22933 . 1546354 . free .

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Aldo-keto reductase family 1 member B10 (AKR1B10)]

Notes and References

1. Hyndman DJ, Flynn TG . Sequence and expression levels in human tissues of a new member of the aldo-keto reductase family . Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression . 1399 . 2–3 . 198–202 . August 1998 . 9765596 . 10.1016/s0167-4781(98)00109-2 .
2. Cao D, Fan ST, Chung SS . Identification and characterization of a novel human aldose reductase-like gene . The Journal of Biological Chemistry . 273 . 19 . 11429–35 . May 1998 . 9565553 . 10.1074/jbc.273.19.11429 . free .
3. Web site: Entrez Gene: AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase).