AKAP8L explained

A-kinase anchor protein 8-like is a protein that in humans is encoded by the AKAP8L gene.^{[1] [2] [3]}

Interactions

AKAP8L has been shown to interact with:

• DHX9,^[4] and
• Thymopoietin.^{[5] [6]}

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–174 . Jan 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Research . 6 . 9 . 791–806 . Sep 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–156 . Oct 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Ueki N, Oda T, Kondo M, Yano K, Noguchi T, Muramatsu M . Selection system for genes encoding nuclear-targeted proteins . Nature Biotechnology . 16 . 13 . 1338–1342 . Dec 1998 . 9853615 . 10.1038/4315 . 20001769 .
• Seki N, Ueki N, Yano K, Saito T, Masuho Y, Muramatsu M . cDNA cloning of a novel human gene NAKAP95, neighbor of A-kinase anchoring protein 95 (AKAP95) on chromosome 19p13.11-p13.12 region . Journal of Human Genetics . 45 . 1 . 0031–0037 . 2000 . 10697960 . 10.1007/s100380070040 . free .
• Yang JP, Tang H, Reddy TR, Wong-Staal F . Mapping the functional domains of HAP95, a protein that binds RNA helicase A and activates the constitutive transport element of type D retroviruses . The Journal of Biological Chemistry . 276 . 33 . 30694–30700 . Aug 2001 . 11402034 . 10.1074/jbc.M102809200 . free .
• Wistow G, Bernstein SL, Ray S, Wyatt MK, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K . Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium . Molecular Vision . 8 . 185–95 . Jun 2002 . 12107412 .
• Martins S, Eikvar S, Furukawa K, Collas P . HA95 and LAP2 beta mediate a novel chromatin-nuclear envelope interaction implicated in initiation of DNA replication . The Journal of Cell Biology . 160 . 2 . 177–188 . Jan 2003 . 12538639 . 2172640 . 10.1083/jcb.200210026 .
• Martins SB, Marstad A, Collas P . In vitro modulation of the interaction between HA95 and LAP2beta by cAMP signaling . Biochemistry . 42 . 35 . 10456–10461 . Sep 2003 . 12950172 . 10.1021/bi0350699 .
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G . A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway . Nature Cell Biology . 6 . 2 . 97–105 . Feb 2004 . 14743216 . 10.1038/ncb1086 . 11683986 .
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proceedings of the National Academy of Sciences of the United States of America . 101 . 33 . 12130–12135 . Aug 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–1178 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Sayer JA, Manczak M, Akileswaran L, Reddy PH, Coghlan VM . Interaction of the nuclear matrix protein NAKAP with HypA and huntingtin: implications for nuclear toxicity in Huntington's disease pathogenesis . Neuromolecular Medicine . 7 . 4 . 297–310 . 2006 . 16391387 . 10.1385/NMM:7:4:297 . 22889682 .

Notes and References

1. Westberg C, Yang JP, Tang H, Reddy TR, Wong-Staal F . A novel shuttle protein binds to RNA helicase A and activates the retroviral constitutive transport element . The Journal of Biological Chemistry . 275 . 28 . 21396–21401 . Jul 2000 . 10748171 . 10.1074/jbc.M909887199 . free .
2. Orstavik S, Eide T, Collas P, Han IO, Taskén K, Kieff E, Jahnsen T, Skålhegg BS . Identification, cloning and characterization of a novel nuclear protein, HA95, homologous to A-kinase anchoring protein 95 . Biology of the Cell . 92 . 1 . 27–37 . Jan 2000 . 10761695 . 10.1016/S0248-4900(00)88761-4 . 1354592 .
3. Web site: Entrez Gene: AKAP8L A kinase (PRKA) anchor protein 8-like.
4. Yang JP, Tang H, Reddy TR, Wong-Staal F . Mapping the functional domains of HAP95, a protein that binds RNA helicase A and activates the constitutive transport element of type D retroviruses . The Journal of Biological Chemistry . 276 . 33 . 30694–700 . Aug 2001 . 11402034 . 10.1074/jbc.M102809200 . free .
5. Martins SB, Eide T, Steen RL, Jahnsen T, Skålhegg BS, Collas P . HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics . Journal of Cell Science . 113 Pt 21 . 3703–13 . Nov 2000 . 21 . 10.1242/jcs.113.21.3703 . 11034899 . free .
6. Martins S, Eikvar S, Furukawa K, Collas P . HA95 and LAP2 beta mediate a novel chromatin-nuclear envelope interaction implicated in initiation of DNA replication . The Journal of Cell Biology . 160 . 2 . 177–88 . Jan 2003 . 12538639 . 2172640 . 10.1083/jcb.200210026 .