AKAP7 explained

A-kinase anchor protein 7 isoform gamma is an enzyme that in humans is encoded by the AKAP7 gene.^{[1] [2]}

Function

This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAPs have a common RII-binding domain, but contain different targeting motifs responsible for directing PKA to distinct intracellular locations.

Further reading

• Gold MG, Smith FD, Scott JD, Barford D . AKAP18 contains a phosphoesterase domain that binds AMP . Journal of Molecular Biology . 375 . 5 . 1329–1343 . Feb 2008 . 18082768 . 3188456 . 10.1016/j.jmb.2007.11.037 .
• Bengrine A, Li J, Awayda MS . The A-kinase anchoring protein 15 regulates feedback inhibition of the epithelial Na+ channel . FASEB Journal . 21 . 4 . 1189–1201 . Apr 2007 . 17244820 . 10.1096/fj.06-6046com . free . 34457423 .
• Brown RL, August SL, Williams CJ, Moss SB . AKAP7gamma is a nuclear RI-binding AKAP . Biochemical and Biophysical Research Communications . 306 . 2 . 394–401 . Jun 2003 . 12804576 . 10.1016/S0006-291X(03)00982-3 .
• Alto NM, Soderling SH, Hoshi N, Langeberg LK, Fayos R, Jennings PA, Scott JD . Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring . Proceedings of the National Academy of Sciences of the United States of America . 100 . 8 . 4445–4450 . Apr 2003 . 12672969 . 153575 . 10.1073/pnas.0330734100 . 2003PNAS..100.4445A . free .
• Trotter KW, Fraser ID, Scott GK, Stutts MJ, Scott JD, Milgram SL . Alternative splicing regulates the subcellular localization of A-kinase anchoring protein 18 isoforms . The Journal of Cell Biology . 147 . 7 . 1481–1492 . Dec 1999 . 10613906 . 2174236 . 10.1083/jcb.147.7.1481 .

Notes and References

1. Fraser ID, Tavalin SJ, Lester LB, Langeberg LK, Westphal AM, Dean RA, Marrion NV, Scott JD . A novel lipid-anchored A-kinase Anchoring Protein facilitates cAMP-responsive membrane events . The EMBO Journal . 17 . 8 . 2261–2272 . Apr 1998 . 9545239 . 1170570 . 10.1093/emboj/17.8.2261 .
2. Web site: Entrez Gene: AKAP7 A kinase (PRKA) anchor protein 7.