AKAP6 explained

A-kinase anchor protein 6 is an enzyme that in humans is encoded by the AKAP6 gene.^{[1] [2] [3]}

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is highly expressed in various brain regions and cardiac and skeletal muscle. It is specifically localized to the sarcoplasmic reticulum and nuclear membrane, and is involved in anchoring PKA to the nuclear membrane or sarcoplasmic reticulum.^[3]

Interactions

AKAP6 has been shown to interact with Ryanodine receptor 2^{[4] [5]} and PDE4D3.^[6]

Further reading

• Lester LB, Scott JD . Anchoring and scaffold proteins for kinases and phosphatases. . Recent Prog. Horm. Res. . 52 . 409–29; discussion 429–30 . 1997 . 9238861 .
• Michel JJ, Scott JD . AKAP mediated signal transduction. . Annu. Rev. Pharmacol. Toxicol. . 42 . 235–57 . 2002 . 11807172 . 10.1146/annurev.pharmtox.42.083101.135801 .
• Nakajima D, Okazaki N, Yamakawa H . Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. . DNA Res. . 9 . 3 . 99–106 . 2003 . 12168954 . 10.1093/dnares/9.3.99 . etal. free .
• Kapiloff MS, Schillace RV, Westphal AM, Scott JD . mAKAP: an A-kinase anchoring protein targeted to the nuclear membrane of differentiated myocytes. . J. Cell Sci. . 112 . 16. 2725–36 . 1999 . 10.1242/jcs.112.16.2725 . 10413680 .
• Marx SO, Reiken S, Hisamatsu Y . PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. . Cell . 101 . 4 . 365–76 . 2000 . 10830164 . 10.1016/S0092-8674(00)80847-8 . etal. free .
• Dodge KL, Khouangsathiene S, Kapiloff MS . mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module. . EMBO J. . 20 . 8 . 1921–30 . 2001 . 11296225 . 10.1093/emboj/20.8.1921 . 125429 . etal.
• Marx SO, Reiken S, Hisamatsu Y . Phosphorylation-dependent regulation of ryanodine receptors: a novel role for leucine/isoleucine zippers. . J. Cell Biol. . 153 . 4 . 699–708 . 2001 . 11352932 . 10.1083/jcb.153.4.699 . 2192391 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal. 2002PNAS...9916899M . free .
• Schulze DH, Muqhal M, Lederer WJ, Ruknudin AM . Sodium/calcium exchanger (NCX1) macromolecular complex. . J. Biol. Chem. . 278 . 31 . 28849–55 . 2003 . 12754202 . 10.1074/jbc.M300754200 . free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .

Notes and References

1. McCartney S, Little BM, Langeberg LK, Scott JD . Cloning and characterization of A-kinase anchor protein 100 (AKAP100). A protein that targets A-kinase to the sarcoplasmic reticulum . J Biol Chem . 270 . 16 . 9327–33 . May 1995 . 7721854 . 10.1074/jbc.270.16.9327. free .
2. Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro . DNA Res . 4 . 2 . 141–50 . Sep 1997 . 9205841 . 10.1093/dnares/4.2.141 . free .
3. Web site: Entrez Gene: AKAP6 A kinase (PRKA) anchor protein 6.
4. 10.1016/S0092-8674(00)80847-8 . Marx . S O . Reiken S. Hisamatsu Y. Jayaraman T. Burkhoff D. Rosemblit N. Marks A R . May 2000 . PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts . Cell . 101 . 4 . 365–76 . UNITED STATES. 0092-8674. 10830164 . free .
5. 10.1083/jcb.153.4.699 . Marx . S O . Reiken S. Hisamatsu Y. Gaburjakova M. Gaburjakova J. Yang Y M. Rosemblit N. Marks A R . May 2001 . Phosphorylation-dependent regulation of ryanodine receptors: a novel role for leucine/isoleucine zippers . J. Cell Biol. . 153 . 4 . 699–708 . United States. 0021-9525. 11352932 . 2192391 .
6. Dodge . K L . Khouangsathiene S. Kapiloff M S. Mouton R. Hill E V. Houslay M D. Langeberg L K. Scott J D . April 2001 . mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module . EMBO J. . 20 . 8 . 1921–30 . England. 0261-4189. 11296225 . 10.1093/emboj/20.8.1921 . 125429 .