AKAP11 explained

A-kinase anchor protein 11 is an enzyme that in humans is encoded by the AKAP11 gene.^{[1] [2] [3]}

Function

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed at high levels throughout spermatogenesis and in mature sperm. It binds the RI and RII subunits of PKA in testis. It may serve a function in cell cycle control of both somatic cells and germ cells in addition to its putative role in spermatogenesis and sperm function.^[3]

Interactions

AKAP11 has been shown to interact with:

• GSK3B,
• PPP1CA,^{[4] [5]}
• PRKAR2A,^{[4] [6]}
• PRKAR2B.^[7]
• VAPB.^[8] Binding is via a FFAT motif in the N-terminal portion of AKAP11, similar to that found in AKAP3. ^[9]

Further reading

• Lester LB, Scott JD . Anchoring and scaffold proteins for kinases and phosphatases . Recent Prog. Horm. Res. . 52 . 409–29; discussion 429–30 . 1997 . 9238861 .
• Michel JJ, Scott JD . AKAP mediated signal transduction . Annu. Rev. Pharmacol. Toxicol. . 42 . 235–57 . 2002 . 11807172 . 10.1146/annurev.pharmtox.42.083101.135801 .
• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T . Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones . DNA Res. . 9 . 3 . 99–106 . 2002 . 12168954 . 10.1093/dnares/9.3.99 . free .
• Schillace RV, Scott JD . Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220 . Curr. Biol. . 9 . 6 . 321–4 . 1999 . 10209101 . 10.1016/S0960-9822(99)80141-9 . free . 1999CBio....9..321S .
• Reinton N, Collas P, Haugen TB, Skâlhegg BS, Hansson V, Jahnsen T, Taskén K . Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis . Dev. Biol. . 223 . 1 . 194–204 . 2000 . 10864471 . 10.1006/dbio.2000.9725 . free .
• Schillace RV, Voltz JW, Sim AT, Shenolikar S, Scott JD . Multiple interactions within the AKAP220 signaling complex contribute to protein phosphatase 1 regulation . J. Biol. Chem. . 276 . 15 . 12128–34 . 2001 . 11152471 . 10.1074/jbc.M010398200 . free .
• Schillace RV, Andrews SF, Liberty GA, Davey MP, Carr DW . Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytes . J. Immunol. . 168 . 4 . 1590–9 . 2002 . 11823486 . 10.4049/jimmunol.168.4.1590 . free .
• Tanji C, Yamamoto H, Yorioka N, Kohno N, Kikuchi K, Kikuchi A . A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta) and mediates protein kinase A-dependent inhibition of GSK-3beta . J. Biol. Chem. . 277 . 40 . 36955–61 . 2002 . 12147701 . 10.1074/jbc.M206210200 . free .
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .

Notes and References

1. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro . DNA Res. . 5 . 3 . 169–76 . December 1998 . 9734811 . 10.1093/dnares/5.3.169 . free .
2. Lester LB, Coghlan VM, Nauert B, Scott JD . Cloning and characterization of a novel A-kinase anchoring protein. AKAP 220, association with testicular peroxisomes . J. Biol. Chem. . 271 . 16 . 9460–5 . June 1996 . 8621616 . 10.1074/jbc.271.16.9460 . free .
3. Web site: Entrez Gene: AKAP11 A kinase (PRKA) anchor protein 11.
4. Tanji C, Yamamoto H, Yorioka N, Kohno N, Kikuchi K, Kikuchi A . A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta) and mediates protein kinase A-dependent inhibition of GSK-3beta . J. Biol. Chem. . 277 . 40 . 36955–61 . October 2002 . 12147701 . 10.1074/jbc.M206210200 . free .
5. Schillace RV, Scott JD . Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220 . Curr. Biol. . 9 . 6 . 321–4 . March 1999 . 10209101 . 10.1016/S0960-9822(99)80141-9 . free . 1999CBio....9..321S .
6. Alto NM, Soderling SH, Hoshi N, Langeberg LK, Fayos R, Jennings PA, Scott JD . Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring . Proc. Natl. Acad. Sci. U.S.A. . 100 . 8 . 4445–50 . April 2003 . 12672969 . 153575 . 10.1073/pnas.0330734100 . 2003PNAS..100.4445A . free .
7. Reinton N, Collas P, Haugen TB, Skâlhegg BS, Hansson V, Jahnsen T, Taskén K . Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis . Dev. Biol. . 223 . 1 . 194–204 . July 2000 . 10864471 . 10.1006/dbio.2000.9725 . free .
8. Huttlin EL, Ting L, Bruckner RJ, Gebreab F, Gygi MP, Szpyt J . The BioPlex Network: A Systematic Exploration of the Human Interactome . Cell . 2015 . 162 . 2 . 425–40 . 26186194 . 10.1016/j.cell.2015.06.043 . 4617211. etal.
9. Mikitova V, Levine TP . Analysis of the key elements of FFAT-like motifs identifies new proteins that potentially bind VAP on the ER, including two AKAPs and FAPP2. . PLOS ONE . 2012 . 7 . 1 . e30455 . 22276202 . 10.1371/journal.pone.0030455 . 3261905 . 2012PLoSO...730455M . free .