AHSA1 explained

Activator of 90 kDa heat shock protein ATPase homolog 1 is an enzyme that in humans is encoded by the AHSA1 gene.^[1]

Interactions

AHSA1 has been shown to interact with Heat shock protein 90kDa alpha (cytosolic), member A1.^[2]

Further reading

• Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL . Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning . Proc. Natl. Acad. Sci. U.S.A. . 97 . 17 . 9543–8 . 2000 . 10931946 . 16901 . 10.1073/pnas.160270997 . 2000PNAS...97.9543H . free .
• Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z . Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells . Genome Res. . 10 . 10 . 1546–60 . 2000 . 11042152 . 310934 . 10.1101/gr.140200 .
• Sevier CS, Machamer CE . p38: A novel protein that associates with the vesicular stomatitis virus glycoprotein . Biochem. Biophys. Res. Commun. . 287 . 2 . 574–82 . 2001 . 11554768 . 10.1006/bbrc.2001.5621 .
• Panaretou B, Siligardi G, Meyer P, Maloney A, Sullivan JK, Singh S, Millson SH, Clarke PA, Naaby-Hansen S, Stein R, Cramer R, Mollapour M, Workman P, Piper PW, Pearl LH, Prodromou C . Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1 . Mol. Cell . 10 . 6 . 1307–18 . 2002 . 12504007 . 10.1016/S1097-2765(02)00785-2 .
• Lotz GP, Lin H, Harst A, Obermann WM . Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone . J. Biol. Chem. . 278 . 19 . 17228–35 . 2003 . 12604615 . 10.1074/jbc.M212761200 . free .
• Swick L, Kapatos G . A yeast 2-hybrid analysis of human GTP cyclohydrolase I protein interactions . J. Neurochem. . 97 . 5 . 1447–55 . 2006 . 16696853 . 2239266 . 10.1111/j.1471-4159.2006.03836.x .
• Wang X, Venable J, LaPointe P, Hutt DM, Koulov AV, Coppinger J, Gurkan C, Kellner W, Matteson J, Plutner H, Riordan JR, Kelly JW, Yates JR, Balch WE . Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis . Cell . 127 . 4 . 803–15 . 2006 . 17110338 . 10.1016/j.cell.2006.09.043 . 1457851 . free .
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .

Notes and References

1. Web site: Entrez Gene: AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast).
2. Panaretou B, Siligardi G, Meyer P, Maloney A, Sullivan JK, Singh S, Millson SH, Clarke PA, Naaby-Hansen S, Stein R, Cramer R, Mollapour M, Workman P, Piper PW, Pearl LH, Prodromou C . Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1 . Mol. Cell . 10 . 6 . 1307–18 . Dec 2002 . 12504007 . 10.1016/S1097-2765(02)00785-2 .