AGXT2 explained

The human AGXT2 gene encodes the protein Alanine—glyoxylate aminotransferase 2.^[1]

Function

The protein encoded by this gene is a class III pyridoxal-phosphate-dependent mitochondrial aminotransferase. It catalyzes the conversion of glyoxylate to glycine using L-alanine as the amino donor.^[2]

Further reading

• Lee IS, Muragaki Y, Ideguchi T, Hase T, Tsuji M, Ooshima A, Okuno E, Kido R . 6 . Molecular cloning and sequencing of a cDNA encoding alanine-glyoxylate aminotransferase 2 from rat kidney . Journal of Biochemistry . 117 . 4 . 856–862 . April 1995 . 7592550 . 10.1093/oxfordjournals.jbchem.a124787 .
• Nicholson G, Rantalainen M, Li JV, Maher AD, Malmodin D, Ahmadi KR, Faber JH, Barrett A, Min JL, Rayner NW, Toft H, Krestyaninova M, Viksna J, Neogi SG, Dumas ME, Sarkans U, Donnelly P, Illig T, Adamski J, Suhre K, Allen M, Zondervan KT, Spector TD, Nicholson JK, Lindon JC, Baunsgaard D, Holmes E, McCarthy MI, Holmes CC . 6 . A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection . PLOS Genetics . 7 . 9 . e1002270 . September 2011 . 21931564 . 3169529 . 10.1371/journal.pgen.1002270 . Barsh . Gregory S . free .
• Suhre K, Wallaschofski H, Raffler J, Friedrich N, Haring R, Michael K, Wasner C, Krebs A, Kronenberg F, Chang D, Meisinger C, Wichmann HE, Hoffmann W, Völzke H, Völker U, Teumer A, Biffar R, Kocher T, Felix SB, Illig T, Kroemer HK, Gieger C, Römisch-Margl W, Nauck M . 6 . A genome-wide association study of metabolic traits in human urine . Nature Genetics . 43 . 6 . 565–569 . June 2011 . 21572414 . 10.1038/ng.837 . 28694666 .
• Rodionov RN, Murry DJ, Vaulman SF, Stevens JW, Lentz SR . Human alanine-glyoxylate aminotransferase 2 lowers asymmetric dimethylarginine and protects from inhibition of nitric oxide production . The Journal of Biological Chemistry . 285 . 8 . 5385–5391 . February 2010 . 20018850 . 2820767 . 10.1074/jbc.M109.091280 . free .
• Baker PR, Cramer SD, Kennedy M, Assimos DG, Holmes RP . Glycolate and glyoxylate metabolism in HepG2 cells . American Journal of Physiology. Cell Physiology . 287 . 5 . C1359–C1365 . November 2004 . 15240345 . 10.1152/ajpcell.00238.2004 .
• Danpure CJ . Primary hyperoxaluria: from gene defects to designer drugs? . Nephrology, Dialysis, Transplantation . 20 . 8 . 1525–1529 . August 2005 . 15956068 . 10.1093/ndt/gfh923 . free .
• Caplin B, Wang Z, Slaviero A, Tomlinson J, Dowsett L, Delahaye M, Salama A, Wheeler DC, Leiper J . 6 . Alanine-glyoxylate aminotransferase-2 metabolizes endogenous methylarginines, regulates NO, and controls blood pressure . Arteriosclerosis, Thrombosis, and Vascular Biology . 32 . 12 . 2892–2900 . December 2012 . 23023372 . 10.1161/ATVBAHA.112.254078 . . free .

Notes and References

1. Web site: Entrez Gene: Alanine--glyoxylate aminotransferase 2. 2014-01-12 .
2. provided by RefSeq, Dec 2008