AGTRAP explained

Type-1 angiotensin II receptor-associated protein is a protein that in humans is encoded by the AGTRAP gene.^{[1] [2]}

This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.

Interactions

AGTRAP has been shown to interact with GNB2L1.

Further reading

• Daviet L, Lehtonen JY, Tamura K . Cloning and characterization of ATRAP, a novel protein that interacts with the angiotensin II type 1 receptor . J. Biol. Chem. . 274 . 24 . 17058–62 . 1999 . 10358057 . 10.1074/jbc.274.24.17058 . etal. free .
• Cui T, Nakagami H, Iwai M . ATRAP, novel AT1 receptor associated protein, enhances internalization of AT1 receptor and inhibits vascular smooth muscle cell growth . Biochem. Biophys. Res. Commun. . 279 . 3 . 938–41 . 2001 . 11162453 . 10.1006/bbrc.2000.4055 . etal.
• Wistow G, Bernstein SL, Wyatt MK . Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants . Mol. Vis. . 8 . 171–84 . 2002 . 12107413 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Lopez-Ilasaca M, Liu X, Tamura K, Dzau VJ . The angiotensin II type I receptor-associated protein, ATRAP, is a transmembrane protein and a modulator of angiotensin II signaling . Mol. Biol. Cell . 14 . 12 . 5038–50 . 2004 . 12960423 . 10.1091/mbc.E03-06-0383 . 284805 .
• Guo DF, Chenier I, Tardif V . Type 1 angiotensin II receptor-associated protein ARAP1 binds and recycles the receptor to the plasma membrane . Biochem. Biophys. Res. Commun. . 310 . 4 . 1254–65 . 2003 . 14559250 . 10.1016/j.bbrc.2003.09.154 . etal.
• Guo DF, Tardif V, Ghelima K . A novel angiotensin II type 1 receptor-associated protein induces cellular hypertrophy in rat vascular smooth muscle and renal proximal tubular cells . J. Biol. Chem. . 279 . 20 . 21109–20 . 2004 . 14985364 . 10.1074/jbc.M401544200 . etal. free.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Guo S, Lopez-Ilasaca M, Dzau VJ . Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of angiotensin II-mediated nuclear factor of activated T cells (NFAT) activation . J. Biol. Chem. . 280 . 13 . 12536–41 . 2005 . 15668245 . 10.1074/jbc.M500296200 . free .
• Tanaka Y, Tamura K, Koide Y . The novel angiotensin II type 1 receptor (AT1R)-associated protein ATRAP downregulates AT1R and ameliorates cardiomyocyte hypertrophy . FEBS Lett. . 579 . 7 . 1579–86 . 2005 . 15757644 . 10.1016/j.febslet.2005.01.068 . etal. 36456303 .
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.
• Gregory SG, Barlow KF, McLay KE . The DNA sequence and biological annotation of human chromosome 1 . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . etal. free .

Notes and References

1. Wang W, Huang Y, Zhou Z, Tang R, Zhao W, Zeng L, Xu M, Cheng C, Gu S, Ying K, Xie Y, Mao Y . Identification and characterization of AGTRAP, a human homolog of murine Angiotensin II Receptor-Associated Protein (Agtrap) . Int J Biochem Cell Biol . 34 . 1 . 93–102 . Dec 2001 . 11733189 . 10.1016/S1357-2725(01)00094-2 .
2. Web site: Entrez Gene: AGTRAP angiotensin II receptor-associated protein.