AGPAT3 explained

1-acyl-sn-glycerol-3-phosphate acyltransferase gamma is an enzyme that in humans is encoded by the AGPAT3 gene.^[1] The protein encoded by this gene is an acyltransferase (specifically, 1-acylglycerol-3-phosphate O-acyltransferase) that converts lysophosphatidic acid (1-acyl-sn-glycerol 3-phosphate) into phosphatidic acid, which is the second step in the de novo phospholipid biosynthetic pathway. The encoded protein may be an integral membrane protein. Two transcript variants encoding the same protein have been found for this gene.

See also

• Stereospecific numbering, for sn-

Further reading

• Leung DW . The structure and functions of human lysophosphatidic acid acyltransferases . Front. Biosci. . 6 . D944–53 . 2001 . 11487472 . 10.2741/Leung . free .
• Wistow G, Bernstein SL, Ray S . Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium . Mol. Vis. . 8 . 185–95 . 2002 . 12107412 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Clark HF, Gurney AL, Abaya E . The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Lu B, Jiang YJ, Zhou Y . Cloning and characterization of murine 1-acyl-sn-glycerol 3-phosphate acyltransferases and their regulation by PPARα in murine heart . Biochem. J. . 385 . Pt 2 . 469–77 . 2005 . 15367102 . 10.1042/BJ20041348 . 1134718 . etal.
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Agarwal AK, Barnes RI, Garg A . Functional characterization of human 1-acylglycerol-3-phosphate acyltransferase isoform 8: cloning, tissue distribution, gene structure, and enzymatic activity . Arch. Biochem. Biophys. . 449 . 1–2 . 64–76 . 2006 . 16620771 . 10.1016/j.abb.2006.03.014 .
• Hu YH, Warnatz HJ, Vanhecke D . Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins . BMC Genomics . 7. 155 . 2006 . 16780588 . 10.1186/1471-2164-7-155 . 1526728 . etal . free .

Notes and References

1. Web site: Entrez Gene: AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3.