AGN-2979 explained

AGN-2979 is a glutarimide tryptophan hydroxylase activation inhibitor.[1] [2] It shows antidepressant properties in rodent models of depression.

Notes and References

  1. Hasegawa S, Kanemaru K, Gittos M, Diksic M . The tryptophan hydroxylase activation inhibitor, AGN-2979, decreases regional 5-HT synthesis in the rat brain measured with alpha-[14C]methyl-L-tryptophan: an autoradiographic study . Brain Research Bulletin . 67 . 3 . 248–55 . October 2005 . 16144662 . 10.1016/j.brainresbull.2005.07.009 . 41905586 .
  2. Gittos MW, Papp M . Antidepressant-like action of AGN 2979, a tryptophan hydroxylase activation inhibitor, in a chronic mild stress model of depression in rats . European Neuropsychopharmacology . 11 . 5 . 351–7 . October 2001 . 11597821 . 10.1016/S0924-977X(01)00103-1 . 46635727 .

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