AGH-107 explained

Iupac Name:	3-(3-ethylimidazol-4-yl)-5-iodo-1H-indole
Width:	180
Cas Number:	2172907-10-5
Pubchem:	138691314
Chemspiderid:	64868965
Unii:	UA8DB5XZ56
Chembl:	4216263
C:	13
H:	12
I:	1
N:	3
Stdinchi:	1S/C13H12IN3/c1-2-17-8-15-7-13(17)11-6-16-12-4-3-9(14)5-10(11)12/h3-8,16H,2H2,1H3
Stdinchikey:	JLCILCCDUVFIRF-UHFFFAOYSA-N
Smiles:	CCn1cncc1-c1c[nH]c2ccc(I)cc12

AGH-107 is a potent, selective, water-soluble and brain penetrant full agonist at the 5HT₇ serotonin receptor.^[1] AGH-107 is one of the few examples of low-basicity aminergic receptor agonists, which may underlie its high selectivity over the related central nervous system targets. AGH-107 was found to reverse the impairment in novel object recognition caused by MK-801 in mice. The relatively short half-life in rodents inhibited its use as a molecular probe.

See also

• AH-494
• AGH-192

Notes and References

1. Hogendorf AS, Hogendorf A, Kurczab R, Satała G, Lenda T, Walczak M, Latacz G, Handzlik J, Kieć-Kononowicz K, Wierońska JM, Woźniak M, Cieślik P, Bugno R, Staroń J, Bojarski AJ . 6 . 7 Receptor Agonists Synthesized Using the van Leusen Multicomponent Protocol . En . Scientific Reports . 7 . 1 . 1444 . May 2017 . 28473721 . 5431432 . 10.1038/s41598-017-00822-4 .