AFF3 explained
AF4/FMR2 family member 3 is a protein that in humans is encoded by the AFF3 gene.[1] [2] [3]
Function
This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved AF4/FMR2 family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.
Further reading
- Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Research . 6 . 9 . 791–806 . Sep 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
- von Bergh AR, Beverloo HB, Rombout P, van Wering ER, van Weel MH, Beverstock GC, Kluin PM, Slater RM, Schuuring E . LAF4, an AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia . Genes, Chromosomes & Cancer . 35 . 1 . 92–6 . Sep 2002 . 12203795 . 10.1002/gcc.10091 . 20750925 .
- Hiwatari M, Taki T, Taketani T, Taniwaki M, Sugita K, Okuya M, Eguchi M, Ida K, Hayashi Y . Fusion of an AF4-related gene, LAF4, to MLL in childhood acute lymphoblastic leukemia with t(2;11)(q11;q23) . Oncogene . 22 . 18 . 2851–5 . May 2003 . 12743608 . 10.1038/sj.onc.1206389 . free .
- Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation . Nature Biotechnology . 22 . 6 . 707–16 . Jun 2004 . 15146197 . 10.1038/nbt971 . 27764390 .
- To MD, Faseruk SA, Gokgoz N, Pinnaduwage D, Done SJ, Andrulis IL . LAF-4 is aberrantly expressed in human breast cancer . International Journal of Cancer . 115 . 4 . 568–74 . Jul 2005 . 15704140 . 10.1002/ijc.20881 . 11311219 .
Notes and References
- Liao X, Ma C, Trask B, Massa H, Gilbert DJ, Staudt LM, Jenkins NA, Copeland NG . LAF4 maps to mouse chromosome 1 and human chromosome 2q11.2-q12 . Mammalian Genome . 7 . 6 . 467–8 . Jun 1996 . 8662235 . 10.1007/s003359900137 . 1525532 .
- Ma C, Staudt LM . LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias . Blood . 87 . 2 . 734–45 . Jan 1996 . 8555498 . 10.1182/blood.V87.2.734.bloodjournal872734. free .
- Web site: Entrez Gene: AFF3 AF4/FMR2 family, member 3.
