| Tourney Name: | AFC Cup |
| Year: | 2005 |
| Dates: | 9 March – 26 October 2005 |
| Num Teams: | 18 |
| Associations: | 9 |
| Champion Other: |  Al-Faisaly |
| Count: | 1 |
| Second Other: | Al-Nejmeh |
| Matches: | 62 |
| Goals: | 167 |
| Top Scorer: | Mo'ayyad Salim (9 goals) |
| Prevseason: | 2004 |
| Nextseason: | 2006 |
The 2005 AFC Cup was the second edition of the AFC Cup, playing among clubs from nations who are members of the Asian Football Confederation.
The 'developing' 9 nations in the Asian Football Confederation were invited to nominate one or two clubs to participate in the 2005 competition.
Central & West Asia
| Jordan (2) | Al-Faisaly (2003–04 Jordan League champions & 2003–04 Jordan FA Cup winners)Al-Hussein (Irbid) (2003–04 Jordan League runners-up) | |
 Lebanon (2) | Al-Nejmeh Beirut (2003–04 Lebanese Premier League champions) Al Ahed Beirut (2004 Lebanese FA Cup winners) | |
 Turkmenistan (2) | Nebitçi Balkanabat (2004 Turkmenistan League champions & 2004 Turkmenistan Cup winners) Nisa Aşgabat (2004 Turkmenistan League runners-up) |
East Asia
 Bangladesh (2) | Brothers Union Dhaka (2004 Bangladesh National Football League champions) Muktijoddha Sangsad Dhaka (2004 Bangladesh National Football League runners-up) | |
 Hong Kong (2) | Sun Hei (2003–04 Hong Kong First Division League champions) Happy Valley (2004 Hong Kong FA Cup winners) | |
 India (2) | East Bengal Club Calcutta (2003–04 Indian National Football League champions) Dempo SC Goa (2004 Indian Federation Cup winners) | |
 Malaysia (2) | Pahang FA (2004 Super League Malaysia champions) Perak FA (2004 Malaysian FA Cup winners) | |
 Maldives (2) | Club Valencia (2004 Dhivehi League champions & 2004 Maldives FA Cup winners) New Radiant (2004 Dhivehi League runners-up) | |
 Singapore (2) | Tampines Rovers FC (2004 S.League champions & 2004 Singapore Cup winners) Home United FC (2004 S.League runners-up) |
Key to colors in group tables:
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Three best runners-up qualify for the quarter-finals.
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First leg
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Second leg
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First leg
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Second leg