AFAP1 explained

Actin filament-associated protein 1 is a protein that in humans is encoded by the AFAP1 gene.^{[1] [2] [3] [4]}

The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Two alternative transcripts encoding the same protein have been identified.^[4]

Further reading

• Ishida Y, Hadano S, Nagayama T . Isolation and characterization of 21 novel expressed DNA sequences from the distal region of human chromosome 4p. . Genomics . 22 . 2 . 302–12 . 1995 . 7545969 . 10.1006/geno.1994.1388 . etal.
• Qian Y, Baisden JM, Westin EH . Src can regulate carboxy terminal interactions with AFAP-110, which influence self-association, cell localization and actin filament integrity. . Oncogene . 16 . 17 . 2185–95 . 1998 . 9619827 . 10.1038/sj.onc.1201753 . etal. 28373925 .
• Guappone AC, Weimer T, Flynn DC . Formation of a stable src-AFAP-110 complex through either an amino-terminal or a carboxy-terminal SH2-binding motif. . Mol. Carcinog. . 22 . 2 . 110–9 . 1998 . 9655255 . 10.1002/(SICI)1098-2744(199806)22:2<110::AID-MC6>3.0.CO;2-Q . 10461528 .
• Qian Y, Baisden JM, Zot HG . The carboxy terminus of AFAP-110 modulates direct interactions with actin filaments and regulates its ability to alter actin filament integrity and induce lamellipodia formation. . Exp. Cell Res. . 255 . 1 . 102–13 . 2000 . 10666339 . 10.1006/excr.1999.4795 . etal.
• Qian Y, Baisden JM, Cherezova L . PC phosphorylation increases the ability of AFAP-110 to cross-link actin filaments. . Mol. Biol. Cell . 13 . 7 . 2311–22 . 2003 . 12134071 . 10.1091/mbc.E01-12-0148 . 117315 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Brandenberger R, Wei H, Zhang S . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. . Nat. Biotechnol. . 22 . 6 . 707–16 . 2005 . 15146197 . 10.1038/nbt971 . 27764390 . etal.
• Ballif BA, Villén J, Beausoleil SA . Phosphoproteomic analysis of the developing mouse brain. . Mol. Cell. Proteomics . 3 . 11 . 1093–101 . 2005 . 15345747 . 10.1074/mcp.M400085-MCP200 . etal. free .
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.
• Kimura K, Wakamatsu A, Suzuki Y . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . etal.
• Dorfleutner A, Stehlik C, Zhang J . AFAP-110 is required for actin stress fiber formation and cell adhesion in MDA-MB-231 breast cancer cells. . J. Cell. Physiol. . 213 . 3 . 740–9 . 2007 . 17520695 . 10.1002/jcp.21143 . etal. 10.1.1.636.3591 . 15344259 .

Notes and References

1. Qian Y, Gatesman AS, Baisden JM, Zot HG, Cherezova L, Qazi I, Mazloum N, Lee MY, Guappone-Koay A, Flynn DC . Analysis of the role of the leucine zipper motif in regulating the ability of AFAP-110 to alter actin filament integrity . J Cell Biochem . 91 . 3 . 602–20 . Feb 2004 . 14755689 . 10.1002/jcb.10725 . 38130241 .
2. Baisden JM, Gatesman AS, Cherezova L, Jiang BH, Flynn DC . The intrinsic ability of AFAP-110 to alter actin filament integrity is linked with its ability to also activate cellular tyrosine kinases . Oncogene . 20 . 45 . 6607–16 . Oct 2001 . 11641786 . 10.1038/sj.onc.1204802 . 21926408 .
3. Baisden JM, Qian Y, Zot HM, Flynn DC . The actin filament-associated protein AFAP-110 is an adaptor protein that modulates changes in actin filament integrity . Oncogene . 20 . 44 . 6435–47 . Oct 2001 . 11607843 . 10.1038/sj.onc.1204784 . free .
4. Web site: Entrez Gene: AFAP1 actin filament associated protein 1.