AEBP2 explained

Adipocyte Enhancer-Binding Protein is a zinc finger protein that in humans is encoded by the evolutionarily well-conserved gene AEBP2. It was initially identified due to its binding capability to the promoter^[1] of the adipocyte P2 gene, and was therefore named Adipocyte Enhancer Binding Protein 2. AEBP2 is a potential targeting protein for the mammalian Polycomb Repression Complex 2 (PRC2).^[2]

Function

AEBP2 is a DNA-binding transcriptional repressor. It may interact with and stimulate the activity of the PRC2 complex.^[3]

AEBP2 may regulate the migration and development of the neural crest cells through the PRC2-mediated epigenetic mechanism and is most likely a targeting protein for the mammalian PRC2 complex.^[4]

Clinical significance

Diseases associated with AEBP2 include Waardenburg's syndrome, and Hirschsprung's disease.^[4]

Notes and References

1. Imhof. Axel. Kim. Hana. Bakshi. Arundhati. Kim. Joomyeong. Retrotransposon-Derived Promoter of Mammalian Aebp2. PLOS ONE. 10. 4. 2015. e0126966. 1932-6203. 10.1371/journal.pone.0126966. 25915901. 4411029. 2015PLoSO..1026966K . free.
2. Kim H, Kang K, Ekram MB, Roh TY, Kim J . Aebp2 as an epigenetic regulator for neural crest cells . PLOS ONE . 6 . 9 . e25174 . 2011 . 21949878 . . 10.1371/journal.pone.0025174 . 2011PLoSO...625174K . free .
3. Cao R, Zhang Y . SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex . Mol. Cell . 15 . 1 . 57–67 . July 2004 . 15225548 . 10.1016/j.molcel.2004.06.020 . free .
4. Kim H, Kang K, Kim J . AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2 . Nucleic Acids Res. . 37 . 9 . 2940–50 . 2009 . 19293275 . 2685092. 10.1093/nar/gkp149 .