ADX71743 explained

ADX71743 is a drug which acts as a potent and selective negative allosteric modulator of the metabotropic glutamate receptor 7.^[1] Few selective ligands are available for this receptor, and so ADX71743 has played an important role into scientific research into the role of this receptor in various processes such as memory formation, nociception, absence seizures and psychosis.^{[2] [3] [4] [5]}

Notes and References

1. Kalinichev M, Rouillier M, Girard F, Royer-Urios I, Bournique B, Finn T, Charvin D, Campo B, Le Poul E, Mutel V, Poli S, Neale SA, Salt TE, Lütjens R . 6 . ADX71743, a potent and selective negative allosteric modulator of metabotropic glutamate receptor 7: in vitro and in vivo characterization . The Journal of Pharmacology and Experimental Therapeutics . 344 . 3 . 624–636 . March 2013 . 23257312 . 10.1124/jpet.112.200915 . 5774001 .
2. Klar R, Walker AG, Ghose D, Grueter BA, Engers DW, Hopkins CR, Lindsley CW, Xiang Z, Conn PJ, Niswender CM . 6 . Activation of Metabotropic Glutamate Receptor 7 Is Required for Induction of Long-Term Potentiation at SC-CA1 Synapses in the Hippocampus . The Journal of Neuroscience . 35 . 19 . 7600–7615 . May 2015 . 25972184 . 10.1523/JNEUROSCI.4543-14.2015 . 4429158 .
3. Moloney RD, Golubeva AV, O'Connor RM, Kalinichev M, Dinan TG, Cryan JF . Negative allosteric modulation of the mGlu7 receptor reduces visceral hypersensitivity in a stress-sensitive rat strain . Neurobiology of Stress . 2015 . 2 . 28–33 . 26844237 . 10.1016/j.ynstr.2015.04.001 . 4721404 .
4. Tassin V, Girard B, Chotte A, Fontanaud P, Rigault D, Kalinichev M, Perroy J, Acher F, Fagni L, Bertaso F . 6 . Phasic and Tonic mGlu7 Receptor Activity Modulates the Thalamocortical Network . Frontiers in Neural Circuits . 2016 . 10 . 31 . 27199672 . 10.3389/fncir.2016.00031 . 4842779 . free .
5. Cieślik P, Woźniak M, Kaczorowska K, Brański P, Burnat G, Chocyk A, Bobula B, Gruca P, Litwa E, Pałucha-Poniewiera A, Wąsik A, Pilc A, Wierońska J . 6 . Negative Allosteric Modulators of mGlu₇ Receptor as Putative Antipsychotic Drugs . Frontiers in Molecular Neuroscience . 2018 . 11 . 316 . 30294258 . 10.3389/fnmol.2018.00316 . 6158327 . free .