ADP-ribosylhydrolase 2 explained

(ADP-ribosyl)hydrolase 2 (ARH2) is a protein that in humans is encoded by the ADPRHL1 gene.[1]

Function

Proteins of the ADP-ribosylhydrolase family are typically associated with the reversal of ADP-ribosylation a posttranslational modification used to regulate protein function. However, ARH2 misses catalytically important residues and is predicted to be catalytically inactive.[2] ARH2 is a cardiac-specific protein and expressed exclusively in the developing heart of vertebrates. Gene loss and loss-of-function mutations are associated with defective heart chamber growth and myofibrillogenesis.[3]

See also

Notes and References

  1. Web site: Entrez Gene: ADP-ribosylhydrolase like 1. 2018-07-12.
  2. Smith SJ, Towers N, Saldanha JW, Shang CA, Mahmood SR, Taylor WR, Mohun TJ . The cardiac-restricted protein ADP-ribosylhydrolase-like 1 is essential for heart chamber outgrowth and acts on muscle actin filament assembly . Developmental Biology . 416 . 2 . 373–88 . August 2016 . 27217161 . 4990356 . 10.1016/j.ydbio.2016.05.006 .
  3. Smith SJ, Towers N, Demetriou K, Mohun TJ . Defective heart chamber growth and myofibrillogenesis after knockout of adprhl1 gene function by targeted disruption of the ancestral catalytic active site . PLOS ONE . 15 . 7 . e0235433 . 2020 . 32726316 . 7390403 . 10.1371/journal.pone.0235433 . 2020PLoSO..1535433S . free .

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