ADP-glyceromanno-heptose 6-epimerase explained

ADP-glyceromanno-heptose 6-epimerase
Ec Number:	5.1.3.20
Cas Number:	85030-75-7
Go Code:	0008712

In enzymology, an ADP-L-glycero-D-manno-heptose 6-epimerase is an enzyme that catalyzes the chemical reaction

ADP-D-glycero-D-manno-heptose

\rightleftharpoons ADP-L-glycero-D-manno-heptose

Hence, this enzyme has one substrate, ADP-D-glycero-D-manno-heptose, and one product, ADP-L-glycero-D-manno-heptose.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on carbohydrates and derivatives. The systematic name of this enzyme class is ADP-L-glycero-D-manno-heptose 6-epimerase. This enzyme participates in lipopolysaccharide biosynthesis. It employs one cofactor, NADP+ in a direct oxidation mechanism.

Structural studies

As of 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .

References

• Read JA, Ahmed RA, Morrison JP, ((Coleman WG Jr)), Tanner ME . 2004 . The Mechanism of the Reaction Catalyzed by ADP-β-L-glycero-D-manno-heptose 6-Epimerase . J. Am. Chem. Soc. . 126 . 29 . 8878 - 9 . 15264802 . 10.1021/ja0485659 .
• Ding L, Seto BL, Ahmed SA, ((Coleman WG Jr)) . 1994 . Purification and properties of the Escherichia coli K-12 NAD-dependent nucleotide diphosphosugar epimerase, ADP-L-glycero-D-mannoheptose 6-epimerase . J. Biol. Chem. . 269 . 24384 - 90 . 7929099 . 39 . 10.1016/S0021-9258(19)51095-X . free .
• Raetz CR . 1990 . Biochemistry of endotoxins . Annu. Rev. Biochem. . 59 . 129 - 70 . 1695830 . 10.1146/annurev.bi.59.070190.001021 .