ADP-dependent short-chain-acyl-CoA hydrolase explained

ADP-dependent short-chain-acyl-CoA hydrolase
Ec Number:	3.1.2.18
Cas Number:	117698-16-5
Go Code:	0047379

The enzyme ADP-dependent short-chain-acyl-CoA hydrolase (EC 3.1.2.18) catalyzes the reaction

acyl-CoA + H₂O

\rightleftharpoons CoA + a carboxylate

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is ADP-dependent-short-chain-acyl-CoA hydrolase. Other names in common use include short-chain acyl coenzyme A hydrolase, propionyl coenzyme A hydrolase, propionyl-CoA hydrolase, propionyl-CoA thioesterase, short-chain acyl-CoA hydrolase, and short-chain acyl-CoA thioesterase. It employs one cofactor, ADP. At least one compound, NADH is known to inhibit this enzyme.

References

• Alexson SE, Nedergaard J . 1988 . A novel type of short- and medium-chain acyl-CoA hydrolases in brown adipose tissue mitochondria . J. Biol. Chem. . 263 . 13564 - 71 . 2901416 . 27 .
• Alexson SE, Svensson LT, Nedergaard J . 1989 . NADH-sensitive propionyl-CoA hydrolase in brown-adipose-tissue mitochondria of the rat . Biochim. Biophys. Acta . 1005 . 13 - 9 . 2570608 . 1 . 10.1016/0005-2760(89)90025-8.