ADP/ATP translocase 3 explained

ADP/ATP translocase 3, also known as solute carrier family 25 member 6, is a protein that in humans is encoded by the SLC25A6 gene.^[1]

Identical copies of this gene reside on the pseudoautosomal regions of the X and Y chromosomes.^[2]

See also

• Adenine nucleotide translocator
• Solute carrier family

Further reading

• Jang JY, Lee CE . Mitochondrial adenine nucleotide translocator 3 is regulated by IL-4 and IFN-gamma via STAT-dependent pathways . Cell. Immunol. . 226 . 1 . 11–9 . 2003 . 14746803 . 10.1016/j.cellimm.2003.11.004 .
• Komaki H, Fukazawa T, Houzen H, etal . A novel D104G mutation in the adenine nucleotide translocator 1 gene in autosomal dominant progressive external ophthalmoplegia patients with mitochondrial DNA with multiple deletions . Ann. Neurol. . 51 . 5 . 645–8 . 2002 . 12112115 . 10.1002/ana.10172 . 38767585 .
• Stelzl U, Worm U, Lalowski M, etal . A human protein-protein interaction network: a resource for annotating the proteome . Cell . 122 . 6 . 957–68 . 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . 11858/00-001M-0000-0010-8592-0 . 8235923 . free .
• Majima E, Takeda M, Miki S, etal . Close location of the first loop to the third loop of the mitochondrial ADP/ATP carrier deduced from cross-linking catalyzed by copper-o-phenanthroline of the solubilized carrier with Triton X-100 . J. Biochem. . 131 . 3 . 461–8 . 2002 . 11872176 . 10.1093/oxfordjournals.jbchem.a003122.
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Zamora M, Granell M, Mampel T, Viñas O . Adenine nucleotide translocase 3 (ANT3) overexpression induces apoptosis in cultured cells . FEBS Lett. . 563 . 1–3 . 155–60 . 2004 . 15063741 . 10.1016/S0014-5793(04)00293-5 . 36314858 . free .
• Hu Z, Guo X, Yu Q, etal . Down-regulation of adenine nucleotide translocase 3 and its role in camptothecin-induced apoptosis in human hepatoma QGY7703 cells . FEBS Lett. . 583 . 2 . 383–8 . 2009 . 19111545 . 10.1016/j.febslet.2008.12.029 . 27745530 .
• De Marcos Lousa C, Trézéguet V, Dianoux AC, etal . The human mitochondrial ADP/ATP carriers: kinetic properties and biogenesis of wild-type and mutant proteins in the yeast S. cerevisiae . Biochemistry . 41 . 48 . 14412–20 . 2002 . 12450408 . 10.1021/bi0261490 .
• Zamora M, Ortega JA, Alaña L. Apoptotic and anti-proliferative effects of all-trans retinoic acid. Adenine nucleotide translocase sensitizes HeLa cells to all-trans retinoic acid . Exp. Cell Res. . 312 . 10 . 1813–9 . 2006 . 16556444 . 10.1016/j.yexcr.2006.02.014 . etal.
• Yang Z, Cheng W, Hong L, etal . Adenine nucleotide (ADP/ATP) translocase 3 participates in the tumor necrosis factor induced apoptosis of MCF-7 cells . Mol. Biol. Cell . 18 . 11 . 4681–9 . 2007 . 17855512 . 10.1091/mbc.E06-12-1161 . 2043556 .
• Tu LC, Yan X, Hood L, Lin B . Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells . Mol. Cell. Proteomics . 6 . 4 . 575–88 . 2007 . 17220478 . 10.1074/mcp.M600249-MCP200 . 7203032 . free.
• Mühlenbein N, Hofmann S, Rothbauer U, Bauer MF . Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria . J. Biol. Chem. . 279 . 14 . 13540–6 . 2004 . 14726512 . 10.1074/jbc.M312485200 . free .
• Verrier F, Mignotte B, Jan G, Brenner C . Study of PTPC composition during apoptosis for identification of viral protein target . Ann. N. Y. Acad. Sci. . 1010 . 1. 126–42 . 2003 . 15033708 . 10.1196/annals.1299.022 . 2003NYASA1010..126V . 22660199 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Napoli L, Bordoni A, Zeviani M, etal . A novel missense adenine nucleotide translocator-1 gene mutation in a Greek adPEO family . Neurology . 57 . 12 . 2295–8 . 2001 . 11756613 . 10.1212/wnl.57.12.2295. 10284753 .
• Chanturiya AN, Basañez G, Schubert U. PB1-F2, an influenza A virus-encoded proapoptotic mitochondrial protein, creates variably sized pores in planar lipid membranes . J. Virol. . 78 . 12 . 6304–12 . 2004 . 15163724 . 10.1128/JVI.78.12.6304-6312.2004 . 416516 . etal.
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Jang JY, Lee CE . IL-4-induced upregulation of adenine nucleotide translocase 3 and its role in Th cell survival from apoptosis . Cell. Immunol. . 241 . 1 . 14–25 . 2006 . 16930576 . 10.1016/j.cellimm.2006.07.006 .
• Zamarin D, García-Sastre A, Xiao X, etal . Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1 . PLOS Pathog. . 1 . 1 . e4 . 2005 . 16201016 . 10.1371/journal.ppat.0010004 . 1238739 . free .
• Deniaud A, Brenner C, Kroemer G . Mitochondrial membrane permeabilization by HIV-1 Vpr . Mitochondrion . 4 . 2–3 . 223–33 . 2004 . 16120388 . 10.1016/j.mito.2004.06.012 .

Notes and References

1. Palmieri F . The mitochondrial transporter family (SLC25): physiological and pathological implications . Pflügers Arch. . 447 . 5 . 689–709 . February 2004 . 14598172 . 10.1007/s00424-003-1099-7 . 25304722 .
2. Slim R, Levilliers J, Lüdecke HJ, Claussen U, Nguyen VC, Gough NM, Horsthemke B, Petit C . A human pseudoautosomal gene encodes the ANT3 ADP/ATP translocase and escapes X-inactivation . Genomics . 16 . 1 . 26–33 . April 1993 . 8486369 . 10.1006/geno.1993.1135 .