ADH7 explained

Alcohol dehydrogenase class 4 mu/sigma chain is an enzyme that in humans is encoded by the ADH7 gene.^{[1] [2]}

Function

This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene makes it much more abundant in the stomach than the liver, thus it differs from the other known gene family members.^[2]

Further reading

• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . Oct 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Xie P, Parsons SH, Speckhard DC, Bosron WF, Hurley TD . X-ray structure of human class IV sigmasigma alcohol dehydrogenase. Structural basis for substrate specificity . The Journal of Biological Chemistry . 272 . 30 . 18558–63 . Jul 1997 . 9228021 . 10.1074/jbc.272.30.18558 . free .
• Yokoyama H, Baraona E, Lieber CS . Molecular cloning and chromosomal localization of the ADH7 gene encoding human class IV (sigma) ADH . Genomics . 31 . 2 . 243–5 . Jan 1996 . 8824810 . 10.1006/geno.1996.0040 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . Jan 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Yokoyama S, Matsuo Y, Ramsbotham R, Yokoyama R . Molecular characterization of a class IV human alcohol dehydrogenase gene (ADH7) . FEBS Letters . 351 . 3 . 411–5 . Sep 1994 . 8082805 . 10.1016/0014-5793(94)00895-7 . 31829053 .
• Yokoyama H, Baraona E, Lieber CS . Molecular cloning of human class IV alcohol dehydrogenase cDNA . Biochemical and Biophysical Research Communications . 203 . 1 . 219–24 . Aug 1994 . 8074657 . 10.1006/bbrc.1994.2170 .
• Farrés J, Moreno A, Crosas B, Peralba JM, Allali-Hassani A, Hjelmqvist L, Jörnvall H, Parés X . Alcohol dehydrogenase of class IV (sigma sigma-ADH) from human stomach. cDNA sequence and structure/function relationships . European Journal of Biochemistry . 224 . 2 . 549–57 . Sep 1994 . 7925371 . 10.1111/j.1432-1033.1994.00549.x . free .
• Zgombić-Knight M, Foglio MH, Duester G . Genomic structure and expression of the ADH7 gene encoding human class IV alcohol dehydrogenase, the form most efficient for retinol metabolism in vitro . The Journal of Biological Chemistry . 270 . 9 . 4305–11 . Mar 1995 . 7876191 . 10.1074/jbc.270.9.4305 . free .
• Kedishvili NY, Bosron WF, Stone CL, Hurley TD, Peggs CF, Thomasson HR, Popov KM, Carr LG, Edenberg HJ, Li TK . Expression and kinetic characterization of recombinant human stomach alcohol dehydrogenase. Active-site amino acid sequence explains substrate specificity compared with liver isozymes . The Journal of Biological Chemistry . 270 . 8 . 3625–30 . Feb 1995 . 7876099 . 10.1074/jbc.270.8.3625 . free .
• Cheung B, Anderson JK, Holmes RS, Beacham IR . Human stomach class IV alcohol dehydrogenase: molecular genetic analysis . Alcoholism: Clinical and Experimental Research . 19 . 1 . 185–6 . Feb 1995 . 7771649 . 10.1111/j.1530-0277.1995.tb01490.x .
• Parés X, Cederlund E, Moreno A, Saubi N, Höög JO, Jörnvall H . Class IV alcohol dehydrogenase (the gastric enzyme). Structural analysis of human sigma sigma-ADH reveals class IV to be variable and confirms the presence of a fifth mammalian alcohol dehydrogenase class . FEBS Letters . 303 . 1 . 69–72 . May 1992 . 1592118 . 10.1016/0014-5793(92)80479-Z . 41630387 . free .

Notes and References

1. Satre MA, Zgombić-Knight M, Duester G . The complete structure of human class IV alcohol dehydrogenase (retinol dehydrogenase) determined from the ADH7 gene . The Journal of Biological Chemistry . 269 . 22 . 15606–12 . Jun 1994 . 10.1016/S0021-9258(17)40724-1 . 8195208 . free .
2. Web site: Entrez Gene: ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide.