ADCY8 explained

Adenylyl cyclase type 8 is an enzyme that in humans is encoded by the ADCY8 gene.^{[1] [2]}

Function

Adenylyl cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (R_s and R_i) interact with G proteins (G_s and G_i) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase.

Further reading

• Stengel D, Parma J, Gannagé MH, Roeckel N, Mattei MG, Barouki R, Hanoune J . Different chromosomal localization of two adenylyl cyclase genes expressed in human brain . Human Genetics . 90 . 1–2 . 126–30 . 1992 . 1427768 . 10.1007/BF00210755 . 1740589 .
• Parma J, Stengel D, Gannage MH, Poyard M, Barouki R, Hanoune J . Sequence of a human brain adenylyl cyclase partial cDNA: evidence for a consensus cyclase specific domain . Biochemical and Biophysical Research Communications . 179 . 1 . 455–62 . Aug 1991 . 1715695 . 10.1016/0006-291X(91)91392-P .
• Cali JJ, Zwaagstra JC, Mons N, Cooper DM, Krupinski J . Type VIII adenylyl cyclase. A Ca2+/calmodulin-stimulated enzyme expressed in discrete regions of rat brain . The Journal of Biological Chemistry . 269 . 16 . 12190–5 . Apr 1994 . 10.1016/S0021-9258(17)32700-X . 8163524 . free .
• Gu C, Cooper DM . Calmodulin-binding sites on adenylyl cyclase type VIII . The Journal of Biological Chemistry . 274 . 12 . 8012–21 . Mar 1999 . 10075700 . 10.1074/jbc.274.12.8012 . free .
• Barcova M, Speth C, Kacani L, Uberall F, Stoiber H, Dierich MP . Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1 . Pflügers Archiv . 437 . 4 . 538–46 . Mar 1999 . 10089566 . 10.1007/s004240050815 . 7620262 .
• Speth C, Joebstl B, Barcova M, Dierich MP . HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones . AIDS . 14 . 6 . 629–36 . Apr 2000 . 10807185 . 10.1097/00002030-200004140-00001 . 22105709 . free .
• Patke CL, Shearer WT . gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression . The Journal of Allergy and Clinical Immunology . 105 . 5 . 975–82 . May 2000 . 10808179 . 10.1067/mai.2000.105315 . free .
• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination . Genome Research . 10 . 11 . 1788–95 . Nov 2000 . 11076863 . 310948 . 10.1101/gr.143000 .
• Patrizio M, Colucci M, Levi G . Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures . Journal of Neurochemistry . 77 . 2 . 399–407 . Apr 2001 . 11299302 . 10.1046/j.1471-4159.2001.00249.x . 24053412 . free .
• Parkinson NA, Bolsover SR . A nuclear location for Ca2+-activated adenylyl cyclases I and III in neurones . Brain Research. Molecular Brain Research . 91 . 1–2 . 43–9 . Jul 2001 . 11457491 . 10.1016/S0169-328X(01)00119-X .
• Speth C, Schabetsberger T, Mohsenipour I, Stöckl G, Würzner R, Stoiber H, Lass-Flörl C, Dierich MP . Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons . Journal of Virology . 76 . 7 . 3179–88 . Apr 2002 . 11884542 . 136041 . 10.1128/JVI.76.7.3179-3188.2002 .
• Ludwig MG, Seuwen K . Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms . Journal of Receptor and Signal Transduction Research . 22 . 1–4 . 79–110 . 2003 . 12503609 . 10.1081/RRS-120014589 . 36697419 .
• Georget M, Mateo P, Vandecasteele G, Lipskaia L, Defer N, Hanoune J, Hoerter J, Lugnier C, Fischmeister R . Cyclic AMP compartmentation due to increased cAMP-phosphodiesterase activity in transgenic mice with a cardiac-directed expression of the human adenylyl cyclase type 8 (AC8) . FASEB Journal . 17 . 11 . 1380–91 . Aug 2003 . 12890691 . 10.1096/fj.02-0784com . free . 17921962 .
• Crossthwaite AJ, Ciruela A, Rayner TF, Cooper DM . A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A . Molecular Pharmacology . 69 . 2 . 608–17 . Feb 2006 . 16258073 . 10.1124/mol.105.018275 . 10661331 .
• Simpson RE, Ciruela A, Cooper DM . The role of calmodulin recruitment in Ca2+ stimulation of adenylyl cyclase type 8 . The Journal of Biological Chemistry . 281 . 25 . 17379–89 . Jun 2006 . 16613843 . 10.1074/jbc.M510992200 . free .
• Nlend MC, Schmid A, Sutto Z, Ransford GA, Conner GE, Fregien N, Salathe M . Calcium-mediated, purinergic stimulation and polarized localization of calcium-sensitive adenylyl cyclase isoforms in human airway epithelia . FEBS Letters . 581 . 17 . 3241–6 . Jul 2007 . 17586501 . 1986749 . 10.1016/j.febslet.2007.06.015 .

Notes and References

1. Defer N, Marinx O, Stengel D, Danisova A, Iourgenko V, Matsuoka I, Caput D, Hanoune J . Molecular cloning of the human type VIII adenylyl cyclase . FEBS Letters . 351 . 1 . 109–13 . Aug 1994 . 8076676 . 10.1016/0014-5793(94)00836-1 . 7559521 . free .
2. Web site: Entrez Gene: ADCY8 adenylate cyclase 8 (brain).