ADCY7 explained

Adenylyl cyclase type 7 is an enzyme that in humans is encoded by the ADCY7 gene.^{[1] [2]}

Function

This gene encodes a membrane-bound adenylyl cyclase that catalyses the formation of cyclic AMP from ATP and is inhibitable by calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme family that is characterized by the presence of twelve membrane-spanning domains in its sequences.

Further reading

• Nomura N, Miyajima N, Sazuka T . Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 . DNA Res. . 1 . 1 . 27–35 . 1995 . 7584026 . 10.1093/dnares/1.1.27 . etal. free .
• Nomura N, Miyajima N, Sazuka T . Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement) . DNA Res. . 1 . 1 . 47–56 . 1995 . 7584028 . 10.1093/dnares/1.1.47 . etal. free .
• Hellevuo K, Welborn R, Menninger JA, Tabakoff B . Human adenylyl cyclase type 7 contains polymorphic repeats in the 3' untranslated region: investigations of association with alcoholism . Am. J. Med. Genet. . 74 . 1 . 95–8 . 1997 . 9034014 . 10.1002/(SICI)1096-8628(19970221)74:1<95::AID-AJMG19>3.0.CO;2-M .
• Barcova M, Speth C, Kacani L . Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1 . Pflügers Arch. . 437 . 4 . 538–46 . 1999 . 10089566 . 10.1007/s004240050815 . 7620262 . etal.
• Speth C, Joebstl B, Barcova M, Dierich MP . HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones . AIDS . 14 . 6 . 629–36 . 2000 . 10807185 . 10.1097/00002030-200004140-00001 . 22105709 . free .
• Patke CL, Shearer WT . gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression . J. Allergy Clin. Immunol. . 105 . 5 . 975–82 . 2000 . 10808179 . 10.1067/mai.2000.105315 . free .
• Patrizio M, Colucci M, Levi G . Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures . J. Neurochem. . 77 . 2 . 399–407 . 2001 . 11299302 . 10.1046/j.1471-4159.2001.00249.x . 24053412 . free .
• Book: Yan SZ, Tang WJ . Construction of Soluble Adenylyl Cyclase from Human Membrane-Bound Type 7 Adenylyl Cyclase . G Protein Pathways - Part C, Effector Mechanisms . 345 . 231–41 . 2002 . 11665607 . 10.1016/S0076-6879(02)45019-7 . Methods in Enzymology . 978-0-12-182246-0 .
• Speth C, Schabetsberger T, Mohsenipour I . Mechanism of Human Immunodeficiency Virus-Induced Complement Expression in Astrocytes and Neurons . J. Virol. . 76 . 7 . 3179–88 . 2002 . 11884542 . 10.1128/JVI.76.7.3179-3188.2002 . 136041 . etal.
• Nelson EJ, Hellevuo K, Yoshimura M, Tabakoff B . Ethanol-induced phosphorylation and potentiation of the activity of type 7 adenylyl cyclase. Involvement of protein kinase C delta . J. Biol. Chem. . 278 . 7 . 4552–60 . 2003 . 12454008 . 10.1074/jbc.M210386200 . free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Ludwig MG, Seuwen K . Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms . J. Recept. Signal Transduct. Res. . 22 . 1–4 . 79–110 . 2003 . 12503609 . 10.1081/RRS-120014589 . 36697419 .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Beeler JA, Yan SZ, Bykov S . A soluble C1b protein and its regulation of soluble type 7 adenylyl cyclase . Biochemistry . 43 . 49 . 15463–71 . 2005 . 15581358 . 10.1021/bi049088+. etal. 10.1.1.558.7519 .
• Kimura K, Wakamatsu A, Suzuki Y . Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . etal.
• Hines LM, Hoffman PL, Bhave S . A sex-specific role of type VII adenylyl cyclase in depression . J. Neurosci. . 26 . 48 . 12609–19 . 2006 . 17135423 . 10.1523/JNEUROSCI.1040-06.2006 . 6674903 . etal. free .

Notes and References

1. Hellevuo K, Berry R, Sikela JM, Tabakoff B . Localization of the gene for a novel human adenylyl cyclase (ADCY7) to chromosome 16 . Hum Genet . 95 . 2 . 197–200 . Mar 1995. 7860067 . 10.1007/bf00209401. 35555146 .
2. Web site: Entrez Gene: ADCY7 adenylate cyclase 7.