ADCY6 explained

Adenylyl cyclase type 6 is an enzyme that in humans is encoded by the ADCY6 gene.^[1]

Function

This gene encodes adenylyl cyclase 6, which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). The expression of this gene is found in normal thyroid and brain tissues, as well as some tumors; and its expression is significantly higher in one hyperfunctioning thyroid tumor than in normal thyroid tissue. Alternative splicing generates 2 transcript variants.

Further reading

• Nakajima D, Okazaki N, Yamakawa H . Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. . DNA Res. . 9 . 3 . 99–106 . 2003 . 12168954 . 10.1093/dnares/9.3.99 . etal. free .
• Gaudin C, Homcy CJ, Ishikawa Y . Mammalian adenylyl cyclase family members are randomly located on different chromosomes. . Hum. Genet. . 94 . 5 . 527–9 . 1994 . 7959689 . 10.1007/BF00211020 . 40521157 .
• Haber N, Stengel D, Defer N . Chromosomal mapping of human adenylyl cyclase genes type III, type V and type VI. . Hum. Genet. . 94 . 1 . 69–73 . 1994 . 8034296 . 10.1007/BF02272844 . 6473135 . etal.
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Harry A, Chen Y, Magnusson R . Differential regulation of adenylyl cyclases by Galphas. . J. Biol. Chem. . 272 . 30 . 19017–21 . 1997 . 9228084 . 10.1074/jbc.272.30.19017 . etal. free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Mhaouty-Kodja S, Bouet-Alard R, Limon-Boulez I . Molecular diversity of adenylyl cyclases in human and rat myometrium. Correlation with global adenylyl cyclase activity during mid- and term pregnancy. . J. Biol. Chem. . 272 . 49 . 31100–6 . 1998 . 9388262 . 10.1074/jbc.272.49.31100 . etal. free .
• Ishikawa K, Nagase T, Nakajima D . Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. . DNA Res. . 4 . 5 . 307–13 . 1998 . 9455477 . 10.1093/dnares/4.5.307 . etal. free .
• Leech CA, Castonguay MA, Habener JF . Expression of adenylyl cyclase subtypes in pancreatic beta-cells. . Biochem. Biophys. Res. Commun. . 254 . 3 . 703–6 . 1999 . 9920805 . 10.1006/bbrc.1998.9906 .
• Barcova M, Speth C, Kacani L . Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1. . Pflügers Arch. . 437 . 4 . 538–46 . 1999 . 10089566 . 10.1007/s004240050815 . 7620262 . etal.
• Raimundo S, Giray J, Volff JN . Cloning and sequence of partial cDNAs encoding the human type V and VI adenylyl cyclases and subsequent RNA-quantification in various tissues. . Clin. Chim. Acta . 285 . 1–2 . 155–61 . 1999 . 10481931 . 10.1016/S0009-8981(99)00067-4 . etal.
• Speth C, Joebstl B, Barcova M, Dierich MP . HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones. . AIDS . 14 . 6 . 629–36 . 2000 . 10807185 . 10.1097/00002030-200004140-00001 . 22105709 . free .
• Patke CL, Shearer WT . gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression. . J. Allergy Clin. Immunol. . 105 . 5 . 975–82 . 2000 . 10808179 . 10.1067/mai.2000.105315 . free .
• Wicker R, Catalan AG, Cailleux A . Cloning and expression of human adenylyl cyclase type VI in normal thyroid tissues. . Biochim. Biophys. Acta . 1493 . 1–2 . 279–83 . 2000 . 10978539 . 10.1016/s0167-4781(00)00187-1. etal.
• Vanvooren V, Allgeier A, Cosson E . Expression of multiple adenylyl cyclase isoforms in human and dog thyroid. . Mol. Cell. Endocrinol. . 170 . 1–2 . 185–96 . 2001 . 11162902 . 10.1016/S0303-7207(00)00322-1 . 20099267 . etal.
• Patrizio M, Colucci M, Levi G . Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures. . J. Neurochem. . 77 . 2 . 399–407 . 2001 . 11299302 . 10.1046/j.1471-4159.2001.00249.x . 24053412 . free .
• Côté M, Guillon G, Payet MD, Gallo-Payet N . Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland. . J. Clin. Endocrinol. Metab. . 86 . 9 . 4495–503 . 2001 . 10.1210/jcem.86.9.7837 . 11549699 . free .
• Speth C, Schabetsberger T, Mohsenipour I . Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons. . J. Virol. . 76 . 7 . 3179–88 . 2002 . 11884542 . 10.1128/JVI.76.7.3179-3188.2002 . 136041 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .

Notes and References

1. Web site: Entrez Gene: ADCY6 adenylate cyclase 6.