ADCY3 explained

Adenylyl cyclase type 3 is an enzyme that in humans is encoded by the ADCY3 gene.^{[1] [2]}

Function

This gene encodes adenylyl cyclase 3, which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP).

The ADCY3 subtype likely mediates odorant detection (possibly) via modulation of intracellular cAMP concentration.^[3]

Further reading

• Gaudin C, Homcy CJ, Ishikawa Y . Mammalian adenylyl cyclase family members are randomly located on different chromosomes . Human Genetics . 94 . 5 . 527–9 . Nov 1994 . 7959689 . 10.1007/BF00211020 . 40521157 .
• Haber N, Stengel D, Defer N, Roeckel N, Mattei MG, Hanoune J . Chromosomal mapping of human adenylyl cyclase genes type III, type V and type VI . Human Genetics . 94 . 1 . 69–73 . Jul 1994 . 8034296 . 10.1007/BF02272844 . 6473135 .
• Hellevuo K, Yoshimura M, Kao M, Hoffman PL, Cooper DM, Tabakoff B . A novel adenylyl cyclase sequence cloned from the human erythroleukemia cell line . Biochemical and Biophysical Research Communications . 192 . 1 . 311–318 . Apr 1993 . 8476432 . 10.1006/bbrc.1993.1415 .
• Wei J, Wayman G, Storm DR . Phosphorylation and inhibition of type III adenylyl cyclase by calmodulin-dependent protein kinase II in vivo . The Journal of Biological Chemistry . 271 . 39 . 24231–24235 . Sep 1996 . 8798667 . 10.1074/jbc.271.39.24231 . free .
• Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro . DNA Research . 5 . 1 . 31–39 . Feb 1998 . 9628581 . 10.1093/dnares/5.1.31 . free .
• Wei J, Zhao AZ, Chan GC, Baker LP, Impey S, Beavo JA, Storm DR . Phosphorylation and inhibition of olfactory adenylyl cyclase by CaM kinase II in Neurons: a mechanism for attenuation of olfactory signals . Neuron . 21 . 3 . 495–504 . Sep 1998 . 9768837 . 10.1016/S0896-6273(00)80561-9 . 9860137 . free .
• Barcova M, Speth C, Kacani L, Uberall F, Stoiber H, Dierich MP . Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1 . Pflügers Archiv . 437 . 4 . 538–546 . Mar 1999 . 10089566 . 10.1007/s004240050815 . 7620262 .
• Speth C, Joebstl B, Barcova M, Dierich MP . HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones . AIDS . 14 . 6 . 629–636 . Apr 2000 . 10807185 . 10.1097/00002030-200004140-00001 . 22105709 . free .
• Patke CL, Shearer WT . gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression . The Journal of Allergy and Clinical Immunology . 105 . 5 . 975–982 . May 2000 . 10808179 . 10.1067/mai.2000.105315 . free .
• Vanvooren V, Allgeier A, Cosson E, Van Sande J, Defer N, Pirlot M, Hanoune J, Dumont JE . Expression of multiple adenylyl cyclase isoforms in human and dog thyroid . Molecular and Cellular Endocrinology . 170 . 1–2 . 185–196 . Dec 2000 . 11162902 . 10.1016/S0303-7207(00)00322-1 . 20099267 .
• Patrizio M, Colucci M, Levi G . Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures . Journal of Neurochemistry . 77 . 2 . 399–407 . Apr 2001 . 11299302 . 10.1046/j.1471-4159.2001.00249.x . 24053412 . free .
• Côté M, Guillon G, Payet MD, Gallo-Payet N . Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland . The Journal of Clinical Endocrinology and Metabolism . 86 . 9 . 4495–4503 . Sep 2001 . 10.1210/jcem.86.9.7837 . 11549699 . free .
• Speth C, Schabetsberger T, Mohsenipour I, Stöckl G, Würzner R, Stoiber H, Lass-Flörl C, Dierich MP . Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons . Journal of Virology . 76 . 7 . 3179–3188 . Apr 2002 . 11884542 . 136041 . 10.1128/JVI.76.7.3179-3188.2002 .
• Kobayakawa K, Hayashi R, Morita K, Miyamichi K, Oka Y, Tsuboi A, Sakano H . Stomatin-related olfactory protein, SRO, specifically expressed in the murine olfactory sensory neurons . The Journal of Neuroscience . 22 . 14 . 5931–7 . Jul 2002 . 12122055 . 10.1523/JNEUROSCI.22-14-05931.2002. 6757947 .
• Ludwig MG, Seuwen K . Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms . Journal of Receptor and Signal Transduction Research . 22 . 1–4 . 79–110 . 2003 . 12503609 . 10.1081/RRS-120014589 . 36697419 .
• Katsel PL, Tagliente TM, Schwarz TE, Craddock-Royal BD, Patel ND, Maayani S . Molecular and biochemical evidence for the presence of type III adenylyl cyclase in human platelets . Platelets . 14 . 1 . 21–33 . Feb 2003 . 12623444 . 10.1080/0953710021000062905 . 7194996 .
• Celano M, Arturi F, Presta I, Bruno R, Scarpelli D, Calvagno MG, Cristofaro C, Bulotta S, Giannasio P, Sacco R, Filetti S, Russo D . Expression of adenylyl cyclase types III and VI in human hyperfunctioning thyroid nodules . Molecular and Cellular Endocrinology . 203 . 1–2 . 129–135 . May 2003 . 12782409 . 10.1016/S0303-7207(03)00086-8 . 24573371 .

Notes and References

1. Yang B, He B, Abdel-Halim SM, Tibell A, Brendel MD, Bretzel RG, Efendic S, Hillert J . Molecular cloning of a full-length cDNA for human type 3 adenylyl cyclase and its expression in human islets . Biochemical and Biophysical Research Communications . 254 . 3 . 548–551 . Jan 1999 . 9920776 . 10.1006/bbrc.1998.9983 .
2. Web site: Entrez Gene: ADCY3 adenylate cyclase 3.
3. Web site: Gene Cards: ADCY3 Gene. 2012-12-30.