ADCY10 explained

See also: Soluble adenylyl cyclase.

Adenylyl cyclase 10 also known as ADCY10 is an enzyme that, in humans, is encoded by the ADCY10 gene.^[1]

Function

The protein encoded by this gene belongs to a distinct class of mammalian adenylyl cyclase that is soluble and insensitive to G protein or forskolin regulation. It is localized in the cytoplasm and is thought to function as a general bicarbonate sensor throughout the body. It may also play an important role in the generation of cAMP in spermatozoa, implying possible roles in sperm maturation through the epididymis, capacitation, hypermotility, and/or the acrosome reaction.^[2]

Clinical significance

Mutations in the ADCY10 gene are associated with an increased risk of adsorptive hypercalciuria^[1] and male infertility.^[3]

External links

Further reading

• Hukovic N, Panetta R, Kumar U, Rocheville M, Patel YC . The cytoplasmic tail of the human somatostatin receptor type 5 is crucial for interaction with adenylyl cyclase and in mediating desensitization and internalization . The Journal of Biological Chemistry . 273 . 33 . 21416–21422 . August 1998 . 9694905 . 10.1074/jbc.273.33.21416 . free .
• Buck J, Sinclair ML, Schapal L, Cann MJ, Levin LR . Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals . Proceedings of the National Academy of Sciences of the United States of America . 96 . 1 . 79–84 . January 1999 . 9874775 . 15096 . 10.1073/pnas.96.1.79 . free . 1999PNAS...96...79B .
• Hayes JS, Lawler OA, Walsh MT, Kinsella BT . The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling . The Journal of Biological Chemistry . 274 . 34 . 23707–23718 . August 1999 . 10446129 . 10.1074/jbc.274.34.23707 . free .
• Sinclair ML, Wang XY, Mattia M, Conti M, Buck J, Wolgemuth DJ, Levin LR . Specific expression of soluble adenylyl cyclase in male germ cells . Molecular Reproduction and Development . 56 . 1 . 6–11 . May 2000 . 10737962 . 10.1002/(SICI)1098-2795(200005)56:1<6::AID-MRD2>3.0.CO;2-M . 34539645 .
• Chen Y, Cann MJ, Litvin TN, Iourgenko V, Sinclair ML, Levin LR, Buck J . Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor . Science . 289 . 5479 . 625–628 . July 2000 . 10915626 . 10.1126/science.289.5479.625 . 2000Sci...289..625C .
• Jaiswal BS, Conti M . Identification and functional analysis of splice variants of the germ cell soluble adenylyl cyclase . The Journal of Biological Chemistry . 276 . 34 . 31698–31708 . August 2001 . 11423534 . 10.1074/jbc.M011698200 . free .
• Reed BY, Gitomer WL, Heller HJ, Hsu MC, Lemke M, Padalino P, Pak CY . Identification and characterization of a gene with base substitutions associated with the absorptive hypercalciuria phenotype and low spinal bone density . The Journal of Clinical Endocrinology and Metabolism . 87 . 4 . 1476–1485 . April 2002 . 11932268 . 10.1210/jc.87.4.1476 . free .
• Zippin JH, Chen Y, Nahirney P, Kamenetsky M, Wuttke MS, Fischman DA, Levin LR, Buck J . Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains . FASEB Journal . 17 . 1 . 82–84 . January 2003 . 12475901 . 10.1096/fj.02-0598fje . free . 22099561 .
• Litvin TN, Kamenetsky M, Zarifyan A, Buck J, Levin LR . Kinetic properties of "soluble" adenylyl cyclase. Synergism between calcium and bicarbonate . The Journal of Biological Chemistry . 278 . 18 . 15922–15926 . May 2003 . 12609998 . 10.1074/jbc.M212475200 . free .
• Jaiswal BS, Conti M . Calcium regulation of the soluble adenylyl cyclase expressed in mammalian spermatozoa . Proceedings of the National Academy of Sciences of the United States of America . 100 . 19 . 10676–10681 . September 2003 . 12958208 . 196863 . 10.1073/pnas.1831008100 . free . 2003PNAS..10010676J .
• Marjanovic JA, Li Z, Stojanovic A, Du X . Stimulatory roles of nitric-oxide synthase 3 and guanylyl cyclase in platelet activation . The Journal of Biological Chemistry . 280 . 45 . 37430–37438 . November 2005 . 16144836 . 10.1074/jbc.M506518200 . free .
• Schmid A, Sutto Z, Nlend MC, Horvath G, Schmid N, Buck J, Levin LR, Conner GE, Fregien N, Salathe M . Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP . The Journal of General Physiology . 130 . 1 . 99–109 . July 2007 . 17591988 . 2154360 . 10.1085/jgp.200709784 .

Notes and References

1. Reed BY, Heller HJ, Gitomer WL, Pak CY . Mapping a gene defect in absorptive hypercalciuria to chromosome 1q23.3-q24 . The Journal of Clinical Endocrinology and Metabolism . 84 . 11 . 3907–3913 . November 1999 . 10566627 . 10.1210/jcem.84.11.6155 . free .
2. Web site: Entrez Gene: ADCY10 .
3. Akbari A, Pipitone GB, Anvar Z, Jaafarinia M, Ferrari M, Carrera P, Totonchi M . ADCY10 frameshift variant leading to severe recessive asthenozoospermia and segregating with absorptive hypercalciuria . Human Reproduction . 34 . 6 . 1155–1164 . June 2019 . 31119281 . 10.1093/humrep/dez048 .