ADCK1 explained

ADCK1 (aarF domain containing kinase 1) is an enzyme that in humans is encoded by the ADCK1 gene. It is situated on chromosome 14 at the q24.3 location.

Function

ADCK1 is predicted to possess ATP binding activity and protein serine/threonine kinase activity. It is involved in the negative regulation of mitochondrial fusion and the positive regulation of cristae formation within mitochondria. The protein is thought to be located predominantly in the mitochondrial inner membrane and may act as an integral component of the mitochondrial membrane.^[1]

Genomic context

The ADCK1 gene is located on chromosome 14q24.3. The genomic sequence spans 134,905 base pairs from 77,800,109 to 77,935,014 on the GRCh38.p14 primary assembly. It consists of 17 exons.^[1]

Expression

ADCK1 is ubiquitously expressed across various human tissues, with notable expression in the brain and thyroid, among others.^[1]

Clinical significance

Research indicates that ADCK1 may have therapeutic implications in diseases such as osteosarcoma and colon cancer.^[2] It has been observed to activate the beta-catenin/TCF signaling pathway, to promote the growth and migration of cancer cells.^[3]

Notes and References

1. Web site: ADCK1 aarF domain containing kinase 1 [Homo sapiens (human)] - Gene. NCBI. 2024-04-27.
2. Zhuo . BB . Zhu . LQ . Yao . C . Wang . XH . Li . SX . Wang . R . Li . Y . Ling . ZY . ADCK1 is a potential therapeutic target of osteosarcoma. . Cell Death & Disease . 12 November 2022 . 13 . 11 . 954 . 10.1038/s41419-022-05401-8 . 36371387. 9653483 .
3. Ji . Y . Liu . Y . Sun . C . Yu . L . Wang . Z . Du . X . Yang . W . Zhang . C . Tao . C . Wang . J . Yang . X . Di . S . Huang . Y . ADCK1 activates the β-catenin/TCF signaling pathway to promote the growth and migration of colon cancer cells. . Cell Death & Disease . 6 April 2021 . 12 . 4 . 354 . 10.1038/s41419-021-03624-9 . 33824271. 8024291 .