ADB-PINACA explained

ADB-PINACA is a cannabinoid designer drug that is an ingredient in some synthetic cannabis products. It is a potent agonist of the CB1 receptor and CB2 receptor with EC50 values of 0.52 nM and 0.88 nM respectively.[1] [2] Like MDMB-FUBINACA, this compound incorporates the unnatural amino acid tert-leucine.

Side effects

ADB-PINACA has been linked to multiple hospitalizations and deaths due to its use.[3] [4] [5]

Metabolism

Nineteen ADB-PINACA major metabolites were identified in several incubations with cryopreserved human hepatocytes. Major metabolic reactions included pentyl hydroxylation, hydroxylation followed by oxidation (ketone formation), and glucuronidation.[6]

Legality

ADB-PINACA is listed in the Fifth Schedule of the Misuse of Drugs Act (MDA) and therefore illegal in Singapore as of May 2015.[7]

In the United States, it is a Schedule I controlled substance.[8] but its 5'-bromo analog ADB-5'Br-PINACA is not as of October 20th, 2023.

As of October 2015 ADB-PINACA is a controlled substance in China.[9]

See also

Notes and References

  1. Banister SD, Moir M, Stuart J, Kevin RC, Wood KE, Longworth M, Wilkinson SM, Beinat C, Buchanan AS, Glass M, Connor M, McGregor IS, Kassiou M . 6 . Pharmacology of Indole and Indazole Synthetic Cannabinoid Designer Drugs AB-FUBINACA, ADB-FUBINACA, AB-PINACA, ADB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA, ADBICA, and 5F-ADBICA . ACS Chemical Neuroscience . 6 . 9 . 1546–59 . September 2015 . 26134475 . 10.1021/acschemneuro.5b00112 .
  2. Web site: ADB-PINACA . Forendex . 2014-07-09 . https://web.archive.org/web/20140714233812/http://forendex.southernforensic.org/index.php/detail/index/1257 . 2014-07-14 . dead .
  3. News: CDC: 221 sickened by synthetic pot in Colorado . USA Today . December 12, 2013.
  4. Schwartz MD, Trecki J, Edison LA, Steck AR, Arnold JK, Gerona RR . A Common Source Outbreak of Severe Delirium Associated with Exposure to the Novel Synthetic Cannabinoid ADB-PINACA . The Journal of Emergency Medicine . 48 . 5 . 573–80 . May 2015 . 25726258 . 10.1016/j.jemermed.2014.12.038 . 9049074 .
  5. Trecki J, Gerona RR, Schwartz MD . Synthetic Cannabinoid-Related Illnesses and Deaths . The New England Journal of Medicine . 373 . 2 . 103–7 . July 2015 . 26154784 . 10.1056/NEJMp1505328 .
  6. Carlier J, Diao X, Scheidweiler KB, Huestis MA . Distinguishing Intake of New Synthetic Cannabinoids ADB-PINACA and 5F-ADB-PINACA with Human Hepatocyte Metabolites and High-Resolution Mass Spectrometry . Clinical Chemistry . 63 . 5 . 1008–1021 . May 2017 . 28302730 . 10.1373/clinchem.2016.267575 . free .
  7. Web site: CNB NEWS RELEASE . Central Narcotics Bureau (CNB) . 30 April 2015 . 24 July 2015 . https://web.archive.org/web/20150715045305/http://www.cnb.gov.sg/Libraries/CNB_Newsroom_Files/CNB_NR_-_30_Apr_2015.sflb.ashx . 15 July 2015 . dead .
  8. Schedules of controlled substances: temporary placement of four synthetic cannabinoids into Schedule I. Final order . Federal Register . 79 . 27 . 7577–82 . February 2014 . 24605391 . Drug Enforcement Administration . Department of Justice .
  9. Web site: 关于印发《非药用类麻醉药品和精神药品列管办法》的通知 . China Food and Drug Administration . 27 September 2015 . Chinese . 1 October 2015 . https://web.archive.org/web/20151001222554/http://www.sfda.gov.cn/WS01/CL0056/130753.html . 1 October 2015 . dead .

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